ژن درمانی – کاربرد های بالقوه نانوفناوری / Gene Therapy

ژن درمانی – کاربرد های بالقوه نانوفناوری Gene Therapy

  • نوع فایل : کتاب
  • زبان : انگلیسی
  • نویسنده : urendra Nimesh
  • چاپ و سال / کشور: 2013
  • تعداد صفحه : 380

Description

Summary: Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy. About the author: Surendra Nimesh, UGC Assistant Professor at Central University of Rajasthan, Rajasthan, India. Surendra received his M.S. in Biomedical Science from the Dr. B.R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi. He completed his PhD. In Nanotechnology at the Institute of Genomics and Integrative Biology (CSIR), Delhi. After completing his postdoctoral studies at the Ecole Polyetchnique of Montreal, Surendra joined the Clinical Research Institute of Montreal (IRCM), Canada as Postdoctoral Fellow. After completing his commitment at IRCM, he joined McGill University for short time. He also worked as NSERC visiting fellow at Health Canada, Canada. His research interests include nanoparticles-mediated gene, siRNA and drug delivery. Contents: Nanotechnology: An introduction; Methods of nanoparticles preparation; Tools and techniques for physicochemical characterization of nanoparticles; In vitro and in vivo characterization of nanoparticles; Theory and limitations to gene therapy; Targeted gene delivery mediated by nanoparticles; Polymeric nanoparticles for gene delivery; Poly-L-lysine; Chitosan; Polyethylenimine; Atelocollagen; Protamine; Dendrimers; Cyclodextrin-containing polymers; PLGA based nanoparticles; Nanomaterials and metallic nanoparticles
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