Human Growth Hormone, Research and Practice

CConOtentsNTENTS vii Preface........................................................................................................ v Contributors .............................................................................................. ix 1 Overview of Human Growth Hormone: Research and Clinical Practice ................................................... 1 Roy G. Smith Part I Research 2 GHRP Historical Perspective: Basic and Clinical ...................................................................... 17 C. Y. Bowers 3 The Design of Peptidomimetic Growth Hormone Secretagogues ............................................................................. 45 Arthur A. Patchett and Matthew J. Wyvratt 4 Molecular Characterization of Growth Hormone Secretagogue Receptors ............................................................. 69 Andrew D. Howard, Scott D. Feighner, Roy G. Smith, and Lex H. T. Van der Ploeg 5 Central Actions of Peptide and Nonpeptide Growth Hormone Secretagogues ............................................... 85 Suzanne L. Dickson and Gareth Leng 6 Pharmacology of Growth Hormone-Releasing Hormone and Its Peptide Analogs .............................................................. 97 David H. Coy 7 Somostatin Receptor Subtypes and Regulation of GH Secretion ........................................................................ 109 Gurkeerat Singh, George Liapakis, and Terry Reisine 8 Mathematical Modeling of the GH Release Axis ........................ 119 David Brown, Elinor A. Stephens, Gareth Leng, and Roy G. Smith 9 Activation of the Human Growth Hormone Receptor: Structure and Function of the Ligand-Receptor Complex ...... 131 Kenneth H. Pearce, Jr. and James A. Wells 10 The Central Nervous System as a Direct Target for Growth Hormone Action .................................................... 145 Pamela A. Bennett and Iain C. A. F. Robinson vii viii Contents Part II Clinical Practice 11 Molecular Defects of the Growth Hormone Axis ........................ 169 Linda Anne DiMeglio, Paul L. Hofman, and Ora Hirsch Pescovitz 12 Growth Hormone: Relevance to Pediatrics ................................. 191 Barry B. Bercu and Howard J. Heinze 13 Growth Hormone Deficiency in Adults: The Rationale for Growth Hormone Replacement .......................................... 221 Paul V. Carroll, Emanuel R. Christ, and Peter H. Sönksen 14 Growth Hormone and Osteoporosis ............................................. 233 Howard B. A. Baum and Anne Klibanski 15 Growth Hormone and Syndrome X .............................................. 247 Gudmundur Johannsson, Per Mårin, Jan-Ove Johansson, and Bengt-Åke Bengtsson 16 Interactions Between Growth Hormone Secretion and Sleep .................................................................................. 261 Eve Van Cauter and Georges Copinschi 17 Growth Hormone in AIDS............................................................ 285 Kathleen Mulligan and Morris Schambelan 18 Clinical and Physiological Studies With Growth Hormone-Releasing Hormone ........................... 297 George R. Merriam and Fernando Cassorla 19 Clinical Use of Growth Hormone Secretagogues ........................ 315 Mark A. Bach and Glenn J. Gormley Index....................................................................................................... 335