Williams manual of hematology, 6th edition

NOTICE EDITORS CONTRIBUTORS PREFACE SI UNIT CONVERSION TABLE COLOR PLATES PART I CLINICAL EVALUATION OF THE PATIENT CHAPTER 1 APPROACH TO THE PATIENT Ernest Beutler / Marshall A. Lichtman / Barry S. Coller / Thomas J. Kipps / Uri Seligsohn / William J. Williams CHAPTER 2 EXAMINATION OF THE BLOOD Daniel H. Ryan CHAPTER 3 EXAMINATION OF THE MARROW Daniel H. Ryan PART II GENERAL HEMATOLOGY CHAPTER 4 STRUCTURE OF THE MARROW AND THE HEMATOPOIETIC MICROENVIRONMENT Camille N. Abboud / Marshall A. Lichtman CHAPTER 5 THE LYMPHOID TISSUES Thomas J. Kipps CHAPTER 6 THE INFLAMMATORY RESPONSE Jeffrey S. Warren / Peter A. Ward CHAPTER 7 HEMATOLOGY OF THE NEWBORN George B. Segel / James Palis CHAPTER 8 HEMATOLOGY IN THE AGED Marshall A. Lichtman / William J. Williams PART III MOLECULAR AND CELLULAR HEMATOLOGY CHAPTER 9 GENETIC PRINCIPLES AND MOLECULAR BIOLOGY Ernest Beutler CHAPTER 10 CYTOGENETICS AND GENE REARRANGEMENT Michelle M. LeBeau CHAPTER 11 APOPTOSIS Roberta A. Gottlieb CHAPTER 12 CELL CYCLE REGULATION AND HEMATOLOGICAL DISORDERS Mathias Schmid / Dennis A. Carson CHAPTER 13 THE CLUSTER OF DIFFERENTIATION ANTIGENS Thomas J. Kipps CHAPTER 14 HEMATOPOIETIC STEM CELLS, PROGENITOR CELLS, AND CYTOKINES Peter J. Quesenberry / Gerald A. Colvin CHAPTER 15 IMMUNE ACCESSORY MOLECULES AND SIGNAL TRANSDUCTION Theodore J. Yun / Edward A. Clark PART IV THERAPEUTIC PRINCIPLES CHAPTER 16 PHARMACOLOGY AND TOXICITY OF ANTINEOPLASTIC DRUGS Bruce A. Chabner / Wyndham Wilson / Jeffrey Supko CHAPTER 17 TREATMENT OF INFECTIONS IN THE IMMUNOCOMPROMISED HOST Steven M. Beutler CHAPTER 18 ALLOGENEIC AND AUTOLOGOUS HEMATOPOIETIC CELL TRANSPLANTATION Robert S. Negrin / Karl G. Blume CHAPTER 19 GENE THERAPY Christopher E. Walsh / Johnson M. Liu / Arthur W. Nienhuis CHAPTER 20 THE USE OF VENOUS ACCESS DEVICES McDonald K. Horne, III / Donna Jo Mayo / Alison G. Freifeld CHAPTER 21 PAIN MANAGEMENT Richard B. Patt / Neil M. Ellison PART V THE ERYTHROCYTE CHAPTER 22 MORPHOLOGY OF THE ERYTHRON Brian S. Bull CHAPTER 23 COMPOSITION OF THE ERYTHROCYTE Ernest Beutler CHAPTER 24 IRON METABOLISM Virgil F. Fairbanks / Ernest Beutler CHAPTER 25 METABOLIC ASPECTS OF FOLIC ACID AND COBALAMIN Bernard M. Babior CHAPTER 26 ENERGY METABOLISM AND MAINTENANCE OF ERYTHROCYTES Ernest Beutler CHAPTER 27 THE RED CELL MEMBRANE Patrick G Gallagher / Bernard G. Forget CHAPTER 28 STRUCTURE AND FUNCTION OF HEMOGLOBIN Helen M. Ranney / Vijay Sharma CHAPTER 29 PRODUCTION AND DESTRUCTION OF ERYTHROCYTES Ernest Beutler CHAPTER 30 CLINICAL MANIFESTATIONS AND CLASSIFICATION OF ERYTHROCYTE DISORDERS Allan J. Erslev CHAPTER 31 APLASTIC ANEMIA Richard K. Shadduck CHAPTER 32 PURE RED CELL APLASIA Allan J. Erslev CHAPTER 33 ANEMIA OF CHRONIC RENAL FAILURE Jaime Caro / Allan J. Erslev CHAPTER 34 ANEMIA OF ENDOCRINE DISORDERS Allan J. Erslev CHAPTER 35 THE CONGENITAL DYSERYTHROPOIETIC ANEMIAS Ernest Beutler CHAPTER 36 PAROXYSMAL NOCTURNAL HEMOGLOBINURIA Ernest Beutler CHAPTER 37 THE MEGALOBLASTIC ANEMIAS Bernard M. Babior CHAPTER 38 IRON DEFICIENCY Virgil F. Fairbanks / Ernest Beutler CHAPTER 39 ANEMIA DUE TO OTHER NUTRITIONAL DEFICIENCIES Ernest Beutler CHAPTER 40 ANEMIA ASSOCIATED WITH MARROW INFILTRATION Allan J. Erslev CHAPTER 41 ANEMIA OF CHRONIC DISEASE Allan J. Erslev CHAPTER 42 DISORDERS OF IRON STORAGE AND TRANSPORT Virgil F. Fairbanks / David J. Brandhagen CHAPTER 43 HEREDITARY SPHEROCYTOSIS, ELLIPTOCYTOSIS, AND RELATED DISORDERS Patrick G. Gallagher / Bernard G. Forget CHAPTER 44 ACANTHOCYTOSIS, STOMATOCYTOSIS, AND RELATED DISORDERS Patrick G. Gallagher CHAPTER 45 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND OTHER RED CELL ENZYME ABNORMALITIES Ernest Beutler CHAPTER 46 THE THALASSEMIAS David J. Weatherall CHAPTER 47 THE SICKLE CELL DISEASES AND RELATED DISORDERS Ernest Beutler CHAPTER 48 HEMOGLOBINOPATHIES ASSOCIATED WITH UNSTABLE HEMOGLOBIN Ernest Beutler CHAPTER 49 METHEMOGLOBINEMIA AND OTHER CAUSES OF CYANOSIS Ernest Beutler CHAPTER 50 TRAUMATIC CARDIAC HEMOLYTIC ANEMIA Allan J. Erslev CHAPTER 51 MICROANGIOPATHIC HEMOLYTIC ANEMIA Jose Martinez CHAPTER 52 MARCH HEMOGLOBINURIA, SPORTS ANEMIA, AND SPACE ANEMIA Allan J. Erslev CHAPTER 53 HEMOLYTIC ANEMIA DUE TO CHEMICAL AND PHYSICAL AGENTS Ernest Beutler CHAPTER 54 HEMOLYTIC ANEMIA DUE TO INFECTIONS WITH MICROORGANISMS Ernest Beutler CHAPTER 55 ACQUIRED HEMOLYTIC ANEMIA DUE TO WARM-REACTING AUTOANTIBODIES Charles H. Packman CHAPTER 56 CRYOPATHIC HEMOLYTIC SYNDROMES Charles H. Packman CHAPTER 57 DRUG-RELATED IMMUNE HEMOLYTIC ANEMIA Charles H. Packman CHAPTER 58 ALLOIMMUNE HEMOLYTIC DISEASE OF THE NEWBORN Jayashree Ramasethu / Naomi L. C. Luban CHAPTER 59 ACUTE BLOOD LOSS ANEMIA Robert S. Hillman / Chaim Hershko CHAPTER 60 HYPERSPLENISM AND HYPOSPLENISM Allan J. Erslev CHAPTER 61 POLYCYTHEMIA Ernest Beutler CHAPTER 62 THE HEMATOLOGIC ASPECTS OF PORPHYRIA Shigeru Sassa CHAPTER 63 HEREDITARY AND ACQUIRED SIDEROBLASTIC ANEMIAS Ernest Beutler PART VI NEUTROPHILS, EOSINOPHILS, BASOPHILS AND MAST CELLS CHAPTER 64 MORPHOLOGY OF NEUTROPHILS, EOSINOPHILS, AND BASOPHILS Dorothy Ford Bainton CHAPTER 65 COMPOSITION AND METABOLISM OF NEUTROPHILS Ernest Beutler CHAPTER 66 PRODUCTION, DISTRIBUTION, AND FATE OF NEUTROPHILS Bernard M. Babior / David W. Golde CHAPTER 67 FUNCTIONS OF NEUTROPHILS James E. Smolen / Laurence A. Boxer CHAPTER 68 EOSINOPHILS AND THEIR DISORDERS A. J. Wardlaw / A. Barry Kay CHAPTER 69 BASOPHILS AND MAST CELLS AND THEIR DISORDERS Stephen J. Galli, Dean D. Metcalfe, Ann M. Dvorak CHAPTER 70 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF NEUTROPHIL DISORDERS Marshall A. Lichtman CHAPTER 71 NEUTROPENIA AND NEUTROPHILIA David C. Dale CHAPTER 72 NEUTROPHIL DISORDERS: QUALITATIVE ABNORMALITIES OF THE NEUTROPHIL Laurence A. Boxer PART VII MONOCYTES AND MACROPHAGES CHAPTER 73 MORPHOLOGY OF MONOCYTES AND MACROPHAGES Steven D. Douglas / Wen-Zhe Ho CHAPTER 74 BIOCHEMISTRY AND FUNCTION OF MONOCYTES AND MACROPHAGES Robert I. Lehrer / Tomas Ganz CHAPTER 75 PRODUCTION, DISTRIBUTION, AND FATE OF MONOCYTES AND MACROPHAGES Tomas Ganz / Robert I. Lehrer CHAPTER 76 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF DISORDERS OF MONOCYTES AND MACROPHAGES Marshall A. Lichtman CHAPTER 77 MONOCYTOSIS AND MONOCYTOPENIA Marshall A. Lichtman CHAPTER 78 INFLAMMATORY AND MALIGNANT HISTIOCYTOSIS Marshall A. Lichtman / Camille N. Abboud CHAPTER 79 LIPID STORAGE DISEASES Ernest Beutler PART VIII LYMPHOCYTES AND PLASMA CELLS CHAPTER 80 MORPHOLOGY OF LYMPHOCYTES AND PLASMA CELLS Stephen M. Baird CHAPTER 81 COMPOSITION AND BIOCHEMISTRY OF LYMPHOCYTES AND PLASMA CELLS Thomas J. Kipps / Dennis A. Carson CHAPTER 82 LYMPHOCYTE ONTOGENY Tucker W. LeBien / Fred E. Bertrand CHAPTER 83 FUNCTIONS OF B LYMPHOCYTES AND PLASMA CELLS IN IMMUNOGLOBULIN PRODUCTION Thomas J. Kipps CHAPTER 84 FUNCTIONS OF T LYMPHOCYTES: T-CELL RECEPTORS FOR ANTIGEN Thomas J. Kipps CHAPTER 85 FUNCTIONS OF NATURAL KILLER CELLS Giorgio Trinchieri / Lewis L. Lanier CHAPTER 86 CLASSIFICATION AND CLINICAL MANIFESTATION OF LYMPHOCYTE AND PLASMA CELL DISORDERS Thomas J. Kipps CHAPTER 87 LYMPHOCYTOSIS AND LYMPHOCYTOPENIA Thomas J. Kipps CHAPTER 88 IMMUNODEFICIENCY DISEASES Fred S. Rosen CHAPTER 89 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) Howard A. Liebman / Timothy P. Cooley / Alexandra M. Levine CHAPTER 90 MONONUCLEOSIS SYNDROMES Kuo-Liang Huang / Robert F. Betts PART IX MALIGNANT DISEASES CHAPTER 91 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF THE CLONAL MYELOID DISORDERS Marshall A. Lichtman CHAPTER 92 MYELODYSPLASTIC DISORDERS (INDOLENT CLONAL MYELOID DISEASES AND OLIGOBLASTIC LEUKEMIA) Marshall A. Lichtman / James K. Brennan CHAPTER 93 ACUTE MYELOGENOUS LEUKEMIA Marshall A. Lichtman / Jane L. Liesveld CHAPTER 94 CHRONIC MYELOGENOUS LEUKEMIA AND RELATED DISORDERS Marshall A. Lichtman / Jane L. Liesveld CHAPTER 95 IDIOPATHIC MYELOFIBROSIS (AGNOGENIC MYELOID METAPLASIA) Marshall A. Lichtman CHAPTER 96 CLASSIFICATION OF MALIGNANT LYMPHOID DISORDERS Thomas J. Kipps CHAPTER 97 ACUTE LYMPHOBLASTIC LEUKEMIA Ching-Hon Piu CHAPTER 98 CHRONIC LYMPHOCYTIC LEUKEMIA AND RELATED DISEASES Thomas J. Kipps CHAPTER 99 HAIRY CELL LEUKEMIA Alan Saven CHAPTER 100 LARGE GRANULAR LYMPHOCYTIC LEUKEMIA Thomas P. Loughran / Marshall E. Kadin CHAPTER 101 PATHOLOGY OF MALIGNANT LYMPHOMAS Peter M. Banks CHAPTER 102 HODGKIN LYMPHOMA Sandra J. Horning CHAPTER 103 LYMPHOMAS Kenneth A. Foon / Richard I. Fisher CHAPTER 104 PLASMA CELL NEOPLASMS: GENERAL CONSIDERATIONS Stephen M. Baird CHAPTER 105 ESSENTIAL MONOCLONAL GAMMOPATHY Marshall A. Lichtman CHAPTER 106 PLASMA CELL MYELOMA Bart Barlogie / John Shaughnessy / Nikhil Munshi / Joshua Epstein CHAPTER 107 THE AMYLOIDOSIS Joel N. Buxbaum / Daniel R. Jacobson CHAPTER 108 WALDENSTRÖM MACROGLOBULINEMIA Thomas J. Kipps CHAPTER 109 HEAVY-CHAIN DISEASES Joel N. Buxbaum / Alice Alexander PART X HEMOSTASIS AND THROMBOSIS CHAPTER 110 MEGAKARYOPOIESIS AND THROMBOPOIESIS David J. Kuter CHAPTER 111 PLATELET MORPHOLOGY, BIOCHEMISTRY AND FUNCTION Leslie V. Parise / Susan S. Smyth / Barry S. Coller CHAPTER 112 MOLECULAR BIOLOGY AND BIOCHEMISTRY OF THE COAGULATION FACTORS AND PATHWAYS OF HEMOSTASIS Harold R. Roberts / Dougald M. Monroe III / Maureane Hoffman CHAPTER 113 CONTROL OF COAGULATION REACTIONS John H. Griffin CHAPTER 114 VASCULAR FUNCTION IN HEMOSTASIS Katherine A. Hajjar / Naomi L. Esmon / Aaron J. Marcus / William Muller CHAPTER 115 CLASSIFICATION, CLINICAL MANIFESTATIONS AND EVALUATION OF DISORDERS OF HEMOSTASIS Uri Seligsohn / Barry S. Coller CHAPTER 116 MOLECULAR MECHANISMS OF FIBRINOLYSIS Katherine A. Hajjar CHAPTER 117 THROMBOCYTOPENIA James N. George / Mujahid A. Rizvi CHAPTER 118 THROMBOCYTOSIS AND ESSENTIAL THROMBOCYTHEMIA Andrew I. Schafer CHAPTER 119 HEREDITARY QUALITATIVE PLATELET DISORDERS Barry S. Coller / Deborah L. French CHAPTER 120 ACQUIRED QUALITATIVE PLATELET DISORDERS DUE TO DISEASES, DRUGS, AND FOODS Sanford J. Shattil / Charles S. Abrams / Joel S. Bennett CHAPTER 121 THE VASCULAR PURPURAS Paul I. Schneiderman CHAPTER 122 INHERITED DEFICIENCIES OF COAGULATION FACTORS II, V, VII, XI, AND XIII AND THE COMBINED DEFICIENCIES OF FACTORS V AND VIII AND OF THE VITAMIN K-DEPENDENT FACTORS Uri Seligsohn / Gilbert C. White, II CHAPTER 123 HEMOPHILIA A AND HEMOPHILIA B Harold R. Roberts / Maureane Hoffman CHAPTER 124 HEREDITARY ABNORMALITIES OF FIBRINOGEN Michael W. Mosesson CHAPTER 125 HEMOSTATIC DYSFUNCTION RELATED TO LIVER DISEASES AND LIVER TRANSPLANTATION Eberhard F. Mammen CHAPTER 126 DISSEMINATED INTRAVASCULAR COAGULATION Uri Seligsohn CHAPTER 127 HEREDITARY THROMBOPHILIA Scott H. Goodnight / John H. Griffin CHAPTER 128 THE ANTIPHOSPHOLIPID SYNDROME Jacob H. Rand CHAPTER 129 VENOUS THROMBOSIS Gary E. Raskob / Russell D. Hull / Graham F. Pineo CHAPTER 130 ATHEROSCLEROSIS, THROMBOSIS, AND CORONARY ARTERY DISEASE Mark B. Taubman CHAPTER 131 ANTIPLATELET THERAPY Harvey J. Weiss CHAPTER 132 ORAL ANTICOAGULATION Sam Schulman CHAPTER 133 HEPARIN, HIRUDIN, AND RELATED AGENTS Gary E. Raskob / Russell D. Hull / Graham F. Pineo CHAPTER 134 FIBRINOLYTIC THERAPY Joseph Loscalzo CHAPTER 135 VON WILLEBRAND DISEASE David Ginsburg CHAPTER 136 DISORDERS OF FIBRINOLYSIS AND USE OF ANTIFIBRINOLYTIC AGENTS Fedor Bachmann PART XI TRANSFUSION MEDICINE CHAPTER 137 ERYTHROCYTE ANTIGENS AND ANTIBODIES Loni Calhoun / Lawrence D. Petz CHAPTER 138 HUMAN LEUKOCYTE AND PLATELET ANTIGENS Karen A. Sullivan / Thomas J. Kipps CHAPTER 139 BLOOD PROCUREMENT AND SCREENING Jeffrey McCullough CHAPTER 140 PRESERVATION AND CLINICAL USE OF ERYTHROCYTES AND WHOLE BLOOD Ernest Beutler CHAPTER 141 COLLECTION AND TRANSFUSION OF LEUKOCYTES, DENDRITIC CELLS, AND STEM CELLS Nicholas A. Bandarenko / Mark E. Brecher CHAPTER 142 PRESERVATION AND CLINICAL USE OF PLATELETS Scott Murphy CHAPTER 143 PREPARATION AND CLINICAL USE OF PLASMA AND PLASMA FRACTIONS Kenneth D. Friedman / Jay E. Menitove CHAPTER 144 THERAPEUTIC HEMAPHERESIS: INDICATIONS, EFFICACY, COMPLICATIONS Bruce C. Mc