The comprehensive sourcebook of bacterial protein toxins, 3rd ed
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : J E Alouf; Michel R Popoff
- ناشر : Amsterdam ; Boston : Elsevier
- چاپ و سال / کشور: 2006
- شابک / ISBN : 9780120884452
Description
Ch. 1. A 116-year story of bacterial protein toxins (1888-2004): from "diphtheritic poison" to molecular toxinology -- Ch. 2. Evolutionary aspects of toxin-producing bacteria -- Ch. 3. Mobile genetic elements and pathogenicity islands encoding bacterial toxins -- Ch. 4. Regulation systems of toxin expression -- Ch. 5. Toxin secretion systems -- Ch. 6. Toxin receptors -- Ch. 7. Translocation of bacterial protein toxin into the cytosol -- Ch. 8. Intracellular trafficking of bacterial and plant protein toxins -- Ch. 9. Bacterial toxins and virulence factors targeting the actin cytoskeleton and intercellular -- Ch. 10. Bacterial toxins and mitochondria -- Ch. 11. Toxins activating Rho GTPases and exploiting the cellular ubiquitin/proteasome machineries -- Ch. 12. Molecular, functional, and evolutionary aspects of ADP-ribosylating toxins -- Ch. 13. Diphtheria toxin -- Ch. 14. Pseudomonas aeruginosa toxins -- Ch. 15. Vibrio cholerae and Escherichia coli thermolabile enterotoxin -- Ch. 16. Bordetella protein toxins -- Ch. 17. The Shiga toxins: properties and action on cells -- Ch. 18. Bacillus anthracis toxins -- Ch. 19. Attack of the nervous system by clostridial toxins: physical findings, cellular and molecular actions -- Ch. 20. Uptake and transport of clostridium neurotoxins -- Ch. 21. Large clostridial cytotoxins modifying small GTPases -- Ch. 22. Pasteurella multocida toxin -- Ch. 23. Cytolethal distending toxins -- Ch. 24. Helicobacter pylori vacuolating toxin -- Ch. 25. Escherichia coli heat-stable enterotoxin b -- Ch. 26. Paradigms and classification of bacterial membrane-damaging toxins -- Ch. 27. . Membrane-damaging and cytotoxic phospholipases -- Ch. 28. Bacteroidesfragilis toxins -- Ch. 29. Structure and mode of action of RTX toxins
Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.
