The adrenal in toxicology : target organ and modulator of toxicity
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Philip W Harvey
- ناشر : London ; Bristol, PA : Taylor & Francis,
- چاپ و سال / کشور: 1996
- شابک / ISBN : 9780203482674
Description
Preface ix Contributors xi SECTION ONE Introduction to Adrenal Gland Involvement in Toxicology 1 1 An overview of adrenal gland involvement in toxicology: from target organ to stress and glucocorticosteroid modulation of toxicity 3 P.W.Harvey SECTION TWO General Endocrinology, Pharmacology and Pathology of the Adrenal Gland Related to Species, Sex and Age and Glucocorticosteroid Actions 21 2 Adrenal morphology and hormone synthesis and regulation 23 J.P.Hinson and P.W.Raven 3 Transport, actions and metabolism of adrenal hormones and pathology and pharmacology of the adrenal gland 53 P.W.Raven and J.P.Hinson 4 Molecular and systems pharmacology of glucocorticosteroids 81 M.Gumbleton and P.J.Nicholls SECTION THREE The Adrenal Gland as a Target Organ 129 5 The adrenal cortex as a toxicological target organ 131 H.D.Colby 6 The adrenal medulla as a toxicological target organ 165 M.J.Tucker Contents viii SECTION FOUR Adrenocortical and Glucocorticosteroid Modulation of Toxicity 183 7 Glucocorticosteroid modulation of toxicity 185 P.W.Harvey 8 Glucocorticosteroids: deleterious effects on neurons and potential exacerbation of environmental neurotoxicity 205 L.J.McIntosh and R.M.Sapolsky 9 Glucocorticosteroids, stress and developmental toxicology 223 J.A.Baldwin 10 Glucocorticosteroids and immunotoxicity 243 I.Kimber SECTION FIVE Clinical Interfaces: Adrenal and Corticosteroid Involvement in Human Toxicology and Extrapolation to Man 259 11 Corticosteroid adverse effects and drug interactions in man 261 P.F.D’Arcy 12 Adverse drug reactions and the adrenal glands: a pharmacoepidemiological approach 279 R.D.Mann 13 Experimental adrenal toxicity: significance of findings and relevance to man 301 A.D.Dayan Index 307
