Systemic lupus erythematosus : a companion to Rheumatology
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : George C Tsokos; Caroline Gordon; Josef S Smolen
- ناشر : Philadelphia : Mosby Elsevier
- چاپ و سال / کشور: 2007
- شابک / ISBN : 9780323044349
Description
Epidemiology and Diagnosis -- 1. Epidemiology -- 2. Disease Activity Measures -- 3. Disease Outcome -- 4. Quality of Life and Economic Aspects -- Pathogenesis -- 1. Overview of the Pathogenesis of SLE -- 2. Genetics -- 3. Hormones -- 4. Immunoregulation -- T Cells, B cells, and cytokines. -- 5. Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs) -- 6. Dendritic Cells -- 7. Apoptosis -- 8. Structure and Origin of Autoantibodies -- 9. Animal Models -- 10. Genetics of murine lupus -- 11. Infection and autoimmunity -- Mechanisms of Tissue Damage -- 1. Complement -- 2. Immune complexes -- 3. Antibodies -- a. ANA and standardization of antibody techniques -- b. Anti-DNA -- c. Anti-splicesomosal ab -- d. Anti-Ro/La -- e. Anti-Histone -- f. APL -- g. Anti-neuronal -- 4. PMNs -- 5. Mechanisms of renal damage -- 6. Mechanisms of vascular damage -- 7. Nitric Oxide -- Clinical Aspects of the Disease -- 1. Constitutional Symptoms and Fatigue -- 2. Skin -- 3. Kidney -- 4. Heart -- 5. Lung -- 6. GI/liver/pancreas -- 7. Infections -- 8. Blood (anti-phospholipid syndrome) -- 9. Nervous System -- 10. Overlap Syndromes -- 11. Ophthalmic Manifestations -- 12. Pregnancy -- 13. Fertility -- 14. Neo-natal lupus -- 15. Hereditary and Malignant Lupus-like Diseases -- Treatment of the Disease -- 1. Non-Steroidals -- Anti-Malarials and Statins -- 2. Steroid Treatment -- 3. Cytotoxic Drug Treatment including M.M.F -- 4. PAPS -- 5. New Treatments.
Offers insights into the causes, detection and therapy of this challenging disease. This resource gives coverage of the scientific and clinical developments in SLE: concepts in epidemiology, disease activity measures and outcomes; concepts in immunoregulation, genetic and pathogenic mechanisms; and comprehensive coverage of clinical features.
