Multiple myeloma and related disorders

PART 1 HISTORY AND EPIDEMIOLOGY 1 1 History of multiple myeloma 3 Robert A. Kyle and David P. Steensma 2 Epidemiology and etiology of plasma cell neoplasms 15 Daniel E. Bergsagel and P. Leif Bergsagel PART 2 BIOLOGY AND PATHOPHYSIOLOGY 27 3 The immune system in myeloma 29 Douglas E. Joshua, P. Joy Ho, John Gibson and Ross D. Brown 4 Molecular biology and cytogenetics 46 Johannes Drach, Jutta Ackermann, Sonja Seidl and Hannes Kaufmann 5 Biology of the malignant plasma cell 58 Federico Caligaris-Cappio 6 Pathophysiology of myeloma bone disease 74 Babatunde O. Oyajobi and Gregory R. Mundy PART 3 CLINICAL FEATURES, DIAGNOSIS, AND INVESTIGATION 89 7 Clinical features 91 Dietrich Peest 8 Hematologic investigations: morphologic and phenotypic features of myeloma marrow diagnosis 102 Thomas M. Grogan, Deborah Gelbspan and Lisa Rimsza 9 Biochemical and immunological investigations 125 Joanna M. Sheldon and Pamela G. Riches 10 The role of imaging in multiple myeloma 155 Brian G.M. Durie 11 Innovative approaches for diagnosis and monitoring 164 Faith E. Davies and Gareth J. Morgan12 Multiple myeloma: differential diagnosis and prognosis 179 Jesús F. San Miguel and Ramón García-Sanz PART 4 TREATMENT OF MYELOMA 201 13 Principles of management 203 Diana M. Samson 14 Chemotherapy, steroids, and interferon 220 Diana M. Samson 15 Radiotherapy Deborah A. Frassica and Maria C. Jacobs 241 16 Autologous stem cell transplantation 250 Jean-Luc Harousseau and Michel Attal 17 Allogeneic transplantation and treatment with donor lymphocytes 260 Gösta Gahrton and Per Ljungman 18 Supportive care 275 Heinz Ludwig and Johannes Drach 19 Biological basis of therapy: new molecular targets 292 Terry H. Landowski and William S. Dalton 20 Immunotherapeutic approaches 305 Håkan Mellstedt PART 5 COMPLICATIONS 317 21 Management of bone disease 319 Eugene V. McCloskey 22 Management of myeloma patients with renal failure 339 Joan Bladé and Laura Rosiñol 23 Neurologic aspects of monoclonal gammopathy of undetermined significance, 350 multiple myeloma, and related disorders Robert A. Kyle and Angela Dispenzieri PART 6 RELATED DISORDERS 367 24 Monoclonal gammopathies of undetermined significance: the transition from MGUS to myeloma 369 John A. Lust, Kathleen A. Donovan and Philip R. Greipp 25 Solitary bone and extramedullary plasmacytoma 379 Meletios A. Dimopoulos and Lia A. Moulopoulos 26 Plasma cell leukaemia 388 Xavier Leleu, Ibrahim Yakoub-Agha and Thierry Facon 27 AL amyloidosis 400 Raymond L. Comenzo 28 Heavy-chain diseases 420 Jean-Paul Fermand and Jean-Claude Brouet 29 Waldenström’s disease 429 Giampaolo Merlini and Steven P. Treon