A textbook of clinical pharmacology and therapeutics,5th ed

PART I GENERAL PRINCIPLES 1 1 Introduction to therapeutics 3 2 Mechanisms of drug action (pharmacodynamics) 6 3 Pharmacokinetics 11 4 Drug absorption and routes of administration 17 5 Drug metabolism 24 6 Renal excretion of drugs 31 7 Effects of disease on drug disposition 34 8 Therapeutic drug monitoring 41 9 Drugs in pregnancy 45 10 Drugs in infants and children 52 11 Drugs in the elderly 56 12 Adverse drug reactions 62 13 Drug interactions 71 14 Pharmacogenetics 79 15 Introduction of new drugs and clinical trials 86 16 Cell-based and recombinant DNA therapies 92 17 Alternative medicines: herbals and nutraceuticals 97 PART II THE NERVOUS SYSTEM 103 18 Hypnotics and anxiolytics 105 19 Schizophrenia and behavioural emergencies 110 20 Mood disorders 116 21 Movement disorders and degenerative CNS disease 124 22 Anti-epileptics 133 23Migraine 142 24 Anaesthetics and muscle relaxants 145 25 Analgesics and the control of pain 155 PART III THE MUSCULOSKELETAL SYSTEM 165 26 Anti-inflammatory drugs and the treatment of arthritis 167 PART IV THE CARDIOVASCULAR SYSTEM 175 27 Prevention of atheroma: lowering plasma cholesterol and other approaches 177 28 Hypertension 185 29 Ischaemic heart disease 196 30 Anticoagulants and antiplatelet drugs 204 31 Heart failure 211 32 Cardiac dysrhythmias 217 PART V THE RESPIRATORY SYSTEM 231 33 Therapy of asthma, chronic obstructive pulmonary disease (COPD) and other respiratory disorders 233 PART VI THE ALIMENTARY SYSTEM 245 34 Alimentary system and liver 247 35 Vitamins and trace elements 265 PART VII FLUIDS AND ELECTROLYTES 271 36 Nephrological and related aspects 273 PART VIII THE ENDOCRINE SYSTEM 283 37 Diabetes mellitus 285 38 Thyroid 292 39 Calcium metabolism 297 40 Adrenal hormones 302 41 Reproductive endocrinology 307 42 The pituitary hormones and related drugs 316 PART IX SELECTIVE TOXICITY 321 43 Antibacterial drugs 323 44 Mycobacterial infections 334 45 Fungal and non-HIV viral infections 340 46 HIV and AIDS 351 47 Malaria and other parasitic infections 361 48 Cancer chemotherapy 367 PART X HAEMATOLOGY 387 49 Anaemia and other haematological disorders 389 PART XI IMMUNOPHARMACOLOGY 397 50 Clinical immunopharmacology 399 PART XII THE SKIN 409 51 Drugs and the skin 411 PART XIII THE EYE 421 52 Drugs and the eye 423 PART XIV CLINICAL TOXICOLOGY 431 53 Drugs and alcohol abuse 433 54 Drug overdose and poisoning 444