Treatment of cancer, 5th ed

PART ONE: PRINCIPLES 1 1 Introduction 3 Karol Sikora 2 Molecular Biology 23 Hani Gabra, Euan Stronach, Rohini Sharma 3 Clinical radiobiology 40 Michele I Saunders, Stanley Dische 4 Mathematical modelling and its application in oncology 58 Roger G Dale, Bleddyn Jones 5 Principles of chemotherapy and drug development 75 Jeffry Evans, Meenali M Chitnis, Denis C Talbot 6 Tumour imaging in oncology 112 Anju Sahdev, Rodney H Reznek 7 Interventional radiology 146 Tarun Sabharwal, Anne P Hemingway, Andreas Adam 8 Vaccination strategies for malignant diseases 167 Deepak P Assudani, Stephanie McArdle, Murrium Ahmad, Geng Li, Robert C Rees, Selman A Ali 9 Biological therapies: cytokines and adoptive cell therapy 186 Fiona C Thistlethwaite, Peter L Stern, Robert E Hawkins 10 Radioimmunotherapy 203 Tim Illidge, Mike Bayne 11 Monoclonal antibodies and treatment of cancer 226 Hossein Borghaei, Liat Binyamin, Igor Astsaturov, Louis M Weiner 12 Angiogenesis as a target for the treatment of cancer 251 Srinivasan Madhusudan, Daniel Patterson, Adrian L Harris 13 Gene therapy 269 Kate Relph, Kevin Harrington, Hardev S Pandha PART TWO: PRACTICE 285 14 Central nervous system 287 Roy Rampling15 Ocular and adnexal tumours 320 John L Hungerford, P Nicholas Plowman 16 Head and neck cancer 343 Alastair J Munro, Nicholas D Stafford 17 Thyroid 408 Masud Haq, Clive Harmer 18 Endocrine cancer 438 Maria Gueorguiev, Ashley B Grossman, P Nicholas Plowman 19 Breast cancer 468 Navita Somaiah, John Yarnold 20 Bronchus 502 Vanessa A Potter, Nicholas Thatcher, Penella J Woll 21 Oesophageal cancer 539 David B Smith, Brian J Haylock 22 Liver 559 Daniel H Palmer, Philip J Johnson, 23 Pancreas 573 Patrick G Johnston, Martin M Eatock 24 Biliary tract 585 Hemant M Kocher, Ajit T Abraham, Satya Bhattacharya 25 Stomach 602 Marianne C Nicolson, Kenneth GM Park, Leslie M Samuel 26 Bladder cancer 614 Robert Huddart, Paula Wells, Alan Horwich 27 Prostate cancer 645 Malcolm Mason 28 Colorectal cancer 666 Richard HJ Begent, Astrid Mayer, Christopher H Collis, Russell N Moule 29 Anus 695 Bernard J Cummings 30 Germ-cell cancers of the testis and related neoplasms 706 Graham M Mead 31 Renal cell cancer 729 Tom R Geldart 32 Ovary and fallopian tubes 748 Daniela D Rosa, Andrew R Clamp, Gordon C Jayson 33 Uterus 764 Bleddyn Jones 34 Cervix 777 Peter Blake 35 Carcinoma of the vagina and vulva 796 Sadaf Ghaem-Maghami, W Pat Soutter 36 Gestational trophoblastic tumours 809 Peter Schmid, Michael J Seckl 37 Non-melanoma skin cancer 835 Stephen L Morris, Sean Whittaker, Margaret Spittle 38 Malignant melanoma 879 Susana Banerjee, Martin Gore 39 Bone 905 Jeremy S Whelan, Rob C Pollock, Anna M Cassoni 40 Soft tissue sarcomas 925 Thomas F DeLaney, Andrew E Rosenberg, David C Harmon, Frances J Hornicek, Sam Yoon, David G Kirsch, Henry J Mankin, Daniel Rosenthal 41 Leukaemias 981 Tariq I Mughal, John M Goldman 42 Hodgkin’s lymphoma 1027 Beate Klimm, Andreas Engert43 Non-Hodgkin’s lymphoma 1045 Adrian J C Bloor, David C Linch 44 Multiple myeloma 1073 Jennifer M Bird, Cathy Williams 45 Introduction to haematopoietic stem cell transplantation 1098 Effie Liakopoulou, David I Marks 46 Paediatric oncology 1118 Stephen Lowis, Eddy Estlin, Keith Sibson, 47 AIDS-related malignancy 1167 Mark Bower, Tom Newsom-Davis PART THREE: MANAGEMENT 1187 48 Medical care 1189 Clare E Green, Richard H J Begent 49 Interstitial brachytherapy 1210 J Roger Owen, David Bottomley 50 Principles of external beam radiotherapy planning techniques 1233 Stephen L Morris, H Jane Dobbs, 51 Conformal radiotherapy, intensity-modulated radiotherapy and image-guided radiotherapy 1254 Vincent Khoo 52 Concomitant chemo-radiotherapy principles and management 1280 Syed A Hussain, Anjali Zarkar, Nicholas D James 53 Palliative care 1290 Anne Naysmith, Karol Sikora 54 Communications with the cancer patient 1305 Justin Stebbing, Maurice L Slevin 55 Clinical cancer genetics 1318 Lisa J Walker, Ros A Eeles 56 Large-scale randomized evidence: trials and overviews 1338 Richard Gray, Rory Collins, Richard Peto, Keith Wheatley 57 The economics of cancer care 1352 Nick Bosanquet 58 Medical audit 1365 Amit K Bahl, Gareth J G Rees, 59 The organisation of cancer services: a UK perspective 1377 Ian Kunkler 60 New drug development 1407 George Blackledge 61 Late effects of cancer therapy 1415 Susan E Davidson 62 Surgical oncology 1423 David Merrilees, David Neal 63 Cancer prevention strategies 1433 William P Steward, Andreas Gescher