Basic clinical radiobiology

Colour plates appear between pages 216 and 217 List of contributors v Preface vii 1 Introduction: the significance of radiobiology and radiotherapy for cancer treatment 1 MC Joiner, AJ van der Kogel and GG Steel 2 Irradiation-induced damage and the DNA damage response 11 BG Wouters and AC Begg 3 Cell death after irradiation: how, when and why cells die 27 BG Wouters 4 Quantifying cell kill and cell survival 41 MC Joiner 5 Dose–response relationships in radiotherapy 56 SM Bentzen 6 Linear energy transfer and relative biological effectiveness 68 MC Joiner 7 Tumour growth and response to radiation 78 D Zips 8 Fractionation: the linear-quadratic approach 102 MC Joiner and SM Bentzen 9 The linear-quadratic approach in clinical practice 120 SM Bentzen and MC Joiner 10 Modified fractionation 135 M Baumann and V Grégoire 11 Time factors in normal-tissue responses to irradiation 149 W Dörr 12 The dose-rate effect 158 AJ van der Kogel 13 Pathogenesis of normal-tissue side-effects 169 W Dörr 14 The volume effect in radiotherapy 191 W Dörr and AJ van der Kogel 15 The oxygen effect and fractionated radiotherapy 207 MR Horsman, BG Wouters, MC Joiner and J Overgaard 16 The tumour microenvironment and cellular hypoxia responses 217 BG Wouters and M Koritzinsky 17 Therapeutic approaches to tumour hypoxia 233 MR Horsman and AJ van der Kogel 18 Combined radiotherapy and chemotherapy 246 V Grégoire and M Baumann 19 Retreatment tolerance of normal tissues 259 W Dörr and FA Stewart 20 Molecular image-guided radiotherapy with positron emission tomography 271 V Grégoire, K Haustermans and J Lee 21 Molecular-targeted agents for enhancing tumour response 287 M Baumann and V Grégoire 22 Biological response modifiers: normal tissues 301 W Dörr 23 Molecular targeting and patient individualization 316 AC Begg 24 Protons and other ions in radiotherapy 332 W Dörr and MC Joiner 25 Second cancers after radiotherapy 339 KR Trott Glossary of terms in radiation biology 353 Index 361