Evaluating clinical research : all that glitters is not gold,2nd ed.
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Bengt Furberg; Curt Furberg
- ناشر : New York : Springer Verlag
- چاپ و سال / کشور: 2007
- شابک / ISBN : 9780387728995
Description
What is the purpose of this book? -- Why is benefit-to-harm balance essential to treatment decisions? -- What are the strengths of randomized controlled clinical trials? -- What are the weaknesses of randomized controlled clinical trials? -- Do meta-analyses provide the ultimate truth? -- What are the strengths of observational studies? -- What are the weaknesses of observational studies? -- Were the scientific questions stated in advance? -- Were the treatment groups comparable initially? -- Why is blinding/masking so important? -- How is symptomatic improvement measured? -- Is it really possible to assess quality of life? -- What is the value of biologic markers in drug evaluation? -- How are adverse drug reactions measured? -- How representative are study subjects in clinical trials? -- What happened to the study subjects who disappeared from the analysis? -- How reliable are active-control trials? -- How informative are composite outcomes? -- Do changes in biologic markers predict clinical benefit? -- How trustworthy are the authors? -- Does publication in a reputable scientific journal guarantee quality? -- Is it necessary to be a biostatistician to interpret scientific data? -- Are all drugs of a class interchangeable? -- How much confidence can be placed on economic analysis? -- How should I handle the massive flow of information? -- How well is research translated into clinical care?
What is the purpose of this book? --
Why is benefit-to-harm balance essential to treatment decisions? --
What are the strengths of randomized controlled clinical trials? --
What are the weaknesses of randomized controlled clinical trials? --
Do meta-analyses provide the ultimate truth? --
What are the strengths of observational studies? --
What are the weaknesses of observational studies? --
Were the scientific questions stated in advance? --
Were the treatment groups comparable initially? --
Why is blinding/masking so important? --
How is symptomatic improvement measured? --
Is it really possible to assess quality of life? --
What is the value of biologic markers in drug evaluation? --
How are adverse drug reactions measured? --
How representative are study subjects in clinical trials? --
What happened to the study subjects who disappeared from the analysis? --
How reliable are active-control trials? --
How informative are composite outcomes? --
Do changes in biologic markers predict clinical benefit? --
How trustworthy are the authors? --
Does publication in a reputable scientific journal guarantee quality? --
Is it necessary to be a biostatistician to interpret scientific data? --
Are all drugs of a class interchangeable? --
How much confidence can be placed on economic analysis? --
How should I handle the massive flow of information? --
How well is research translated into clinical care?
Why is benefit-to-harm balance essential to treatment decisions? --
What are the strengths of randomized controlled clinical trials? --
What are the weaknesses of randomized controlled clinical trials? --
Do meta-analyses provide the ultimate truth? --
What are the strengths of observational studies? --
What are the weaknesses of observational studies? --
Were the scientific questions stated in advance? --
Were the treatment groups comparable initially? --
Why is blinding/masking so important? --
How is symptomatic improvement measured? --
Is it really possible to assess quality of life? --
What is the value of biologic markers in drug evaluation? --
How are adverse drug reactions measured? --
How representative are study subjects in clinical trials? --
What happened to the study subjects who disappeared from the analysis? --
How reliable are active-control trials? --
How informative are composite outcomes? --
Do changes in biologic markers predict clinical benefit? --
How trustworthy are the authors? --
Does publication in a reputable scientific journal guarantee quality? --
Is it necessary to be a biostatistician to interpret scientific data? --
Are all drugs of a class interchangeable? --
How much confidence can be placed on economic analysis? --
How should I handle the massive flow of information? --
How well is research translated into clinical care?
