The toxicology of fishes

Contents Acknowledgments....................................................................................................... xi The Editors ................................................................................................................xiii Contributors ............................................................................................................... xv Unit I. General Principles 1 Introduction ..........................................................................................................3 Richard T. Di Giulio and David E. Hinton 2 Bioavailability of Chemical Contaminants in Aquatic Systems ....................9 Russell J. Erickson, John W. Nichols, Philip M. Cook, and Gerald T. Ankley 3 Toxicokinetics in Fishes ....................................................................................55 Kevin M. Kleinow, John W. Nichols, William L. Hayton, James M. McKim, and Mace G. Barron 4 Biotransformation in Fishes............................................................................153 Daniel Schlenk, Malin Celander, Evan P. Gallagher, Stephen George, Margaret James, Seth W. Kullman, Peter van den Hurk, and Kristie Willett 5 Receptor-Mediated Mechanisms of Toxicity .................................................235 Mark E. Hahn and Eli V. Hestermann 6 Reactive Oxygen Species and Oxidative Stress............................................273 Richard T. Di Giulio and Joel N. Meyer Unit II. Key Target Systems and Organismal Effects 7 Liver Toxicity ....................................................................................................327 David E. Hinton, Helmut Segner, Doris W.T. Au, Seth W. Kullman, and Ronald C. Hardman 8 The Osmoregulatory System...........................................................................401 Sjoerd E. Wendelaar Bonga and Robert A.C. Lock viii The Toxicology of Fishes 9 Toxic Responses of the Fish Nervous System ..............................................417 Steven P. Bradbury, Richard W. Carlson, Tala R. Henry, Stephanie Padilla, and John Cowden 10 The Endocrine System .....................................................................................457 Peter Thomas 11 The Immune System of Fish: A Target Organ of Toxicity ..........................489 Erik Carlson and Judith T. Zelikoff 12 Chemical Carcinogenesis in Fishes................................................................531 Jeanette M. Rotchell, Michael R. Miller, David E. Hinton, Richard T. Di Giulio, and Gary K. Ostrander 13 Toxicity Resistance ...........................................................................................597 Peter A. Van Veld and Diane E. Nacci Unit III. Methodologies and Applications 14 Exposure Assessment and Modeling in the Aquatic Environment ...........645 Donald Mackay and Lynne Milford 15 Fish Toxicity Studies........................................................................................659 Gary M. Rand 16 Biomarkers ........................................................................................................683 Daniel Schlenk, Richard Handy, Scott Steinert, Michael H. Depledge, and William Benson 17 Aquatic Ecosystems for Ecotoxicological Research: Considerations in Design Analysis for Fish.................................................733 Thomas W. La Point, James H. Kennedy, Jacob K. Stanley, and Pinar Balci 18 Ecological Risk Assessment ............................................................................757 David R. Mount and Tala R. Henry Unit IV. Case Studies 19 Mining Impacts on Fish in the Clark Fork River, Montana: A Field Ecotoxicology Case Study .................................................................779 Samuel N. Luoma, Johnnie N. Moore, Aïda Farag, Tracy H. Hillman, Daniel J. Cain, and Michelle Hornberger 20 Toxicology of Synthetic Pyrethroid Insecticides in Fish: A Case Study .....805 Joel R. Coats Contents ix 21 Reproductive Impairment of Great Lakes Lake Trout by Dioxin-Like Chemicals...........................................................819 Donald E. Tillitt, Philip M. Cook, John P. Giesy, Warren Heideman, and Richard E. Peterson 22 The Effects of Polycyclic Aromatic Hydrocarbons in Fish from Puget Sound, Washington ........................................................877 Lyndal L. Johnson, Mary R. Arkoosh, Claudia F. Bravo, Tracy K. Collier, Margaret M. Krahn, James P. Meador, Mark S. Myers, William L. Reichert, and John E. Stein 23 Effects of the Exxon Valdez Oil Spill on Pacific Herring in Prince William Sound, Alaska ...................................................................925 Gary D. Marty 24 Case Study: Pulp and Paper Mill Impacts ....................................................933 Monique G. Dubé, Kelly R. Munkittrick, and L. Mark Hewitt 25 Estrogenic Effects of Treated Sewage Effluent on Fish: Steroids and Surfactants in English Rivers ..................................................971 Charles R. Tyler, Edwin J. Routledge, and Ronny van Aerle Index......................................................................................................................... 1003