Fatty acids and lipotoxicity in obesity and diabetes

Symposium on Fatty acids and lipotoxicity in obesity and diabetes, held at Tsinghua University, Beijing, China, 17-19 October 2006. Editors: Gregory Bock (Organizer) and Jamie Goode. This symposium is based on a proposal made by Peng Li. Bruce M. Spiegelman - Chair's introduction. Bruce M. Spiegelman - Transcriptional control of energy homeostasis through the PGC1 coactivators. Discussion. Stephen O'Rahilly - Human obesity and insulin resistance: lessons from experiments of nature. Discussion. Deborah M. Muoio and Timothy R. Koves - Lipid-induced metabolic dysfunction in skeletal muscle. Discussion. Alan D. Attie, Matthew T. Flowers, Jessica B. Flowers, Albert K. Groen, Folkert Kuipers and James M. Ntambi - Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes. Discussion. Karen Reue - The role of lipin 1 in adipogenesis and lipid metabolism. Discussion. David Carling - The role of the AMP-activated protein kinase in the regulation of energy homeostasis. Discussion. Gokhan S. Hotamisligil - Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes. Discussion. Ira Tabas, Tracie Seimon, Jerry Arellano, Yankun Li, Fabien Forcheron, Dongying Cui, Seongah Han, Chien-Ping Liang, Alan Tall and Domenico Accili - The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis. Discussion. Sandra Lobo and David A. Bernlohr - Fatty acid transport in adipocytes and the development of insulin resistance. Discussion. Paul N. Black and Concetta C. DiRusso - Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking. Discussion. Gunther Daum, Andrea Wagner, Tibor Czabany, Karlheinz Grillitsch and Karin Athenstaedt - Lipid storage and mobilization pathways in yeast. Discussion. John Zhong Li and Peng Li - Cide proteins and the development of obesity. Discussion. General discussion I. Visualizing brown adipose tissue with FDG-PET. Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara and Kohjiro Ueki - Adiponectin and adiponectin receptors in obesity-linked insulin resistance. Discussion. Gabriel Pascual, Amy L. Sullivan, Sumito Ogawa, Amir Gamliel, Valentina Perissi, Michael G. Rosenfeld and Christopher K. Glass -Anti-inflammatory and antidiabetic roles of PPARgamma. Discussion. Final discussion. Nutrition, ageing and lipotoxicity. Index of contributors. Subject index.