Wintrobe's clinical hematology.

PART I. INTRODUCTION Chapter 1. The Diagnostic and Therapeutic Approach to Hematologic Problems Maxwell M. Wintrobe PART II. LABORATORY HEMATOLOGY Chapter 2. Examination of the Blood and Bone Marrow Sherrie L. Perkins Chapter 3. Immunodiagnosis Frixos Paraskevas and John Foerster Chapter 4. Clinical Flow Cytometry Frixos Paraskevas Chapter 5. Clusters of Differentiation Frixos Paraskevas Chapter 6. Cytogenetics Maria R. Baer Chapter 7. Molecular Genetics and Hematology Rebecca L. Shattuck-Brandt and Stephen J. Brandt PART III. THE NORMAL HEMATOLOGIC SYSTEM Section 1. Hematopoiesis Chapter 8. Origin and Development of Blood Cells Maurice C. Bondurant and Mark J. Koury Section 2. The Erythrocyte Chapter 9. Erythropoiesis Emmanuel N. Dessypris Chapter 10. The Mature Erythrocyte Marilyn J. Telen and Russel E. Kaufman Chapter 11. Nutritional Factors in the Production and Function of Erythrocytes G. Richard Lee and Victor D. Herbert Chapter 12. Destruction of Erythrocytes Andrew Deiss Section 3. Granulocytes and Monocytes Chapter 13. Neutrophilic Leukocytes Keith M. Skubitz Chapter 14. The Human Eosinophil Redwan Moqbel and Allan B. Becker Chapter 15. Basophilic Leukocytes: Mast Cells and Basophils A. Dean Befus and Judah A. Denburg Chapter 16. Mononuclear Phagocytes J. Brice Weinberg Chapter 17. Phagocytosis Frixos Paraskevas Section 4. The Lymphocytes Chapter 18. The Lymphatic System Frixos Paraskevas and John Foerster Chapter 19. B Lymphocytes Frixos Paraskevas Chapter 20. T Lymphocytes and NK Cells Frixos Paraskevas Chapter 21. Cell Interactions in the Immune Response Frixos Paraskevas Section 5. Hemostasis Chapter 22. Platelets and Megakaryocytes Paula E. Stenberg and Ronald J. Hill Chapter 23. Platelets in Hemostasis and Thrombosis Leslie V. Parise, Christel Boudignon-Proudhon, Patricia J. Keely and Ulhas P. Naik Chapter 24. Blood Coagulation and Fibrinolysis Charles S. Greenberg and Carolyn L. Orthner Chapter 25. Endothelium and the Regulation of Hemostasis George M. Rodgers Section 6. Transfusion and Transplantation Chapter 26. Red Cell, Platelet, and White Cell Antigens Marlis L. Schroeder Chapter 27. Principles and Practice of Transfusion Medicine Marlis L. Schroeder Chapter 28. Hematopoietic Stem Cell Transplantation Richard A. Nash PART IV. DISORDERS OF RED CELLS Section 1. Anemia: General Considerations Chapter 29. Anemia: General Aspects G. Richard Lee Chapter 30. Anemia: A Diagnostic Strategy G. Richard Lee Section 2. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis Chapter 31. Pernicious Anemia and Other Causes of Vitamin B12 (Cobalamin) Deficiency G. Richard Lee Chapter 32. Folate Deficiency: Causes and Management G. Richard Lee Chapter 33. Inherited and Drug-Induced Megaloblastic Anemia G. Richard Lee Section 3. Disorders of Iron Metabolism and Heme Synthesis Chapter 34. Iron Deficiency and Iron-Deficiency Anemia G. Richard Lee Chapter 35. The Anemia of Chronic Disorders Robert T. Means, Jr Chapter 36. Sideroblastic Anemias Sylvia S. Bottomley Chapter 37. Methemoglobinemia and Other Disorders Accompanied by Cyanosis John N. Lukens Chapter 38. Hemochromatosis Corwin Q. Edwards Chapter 39. Porphyria Sylvia S. Bottomley and G. Richard Lee Section 4. Hemolytic Anemia Chapter 40. Hemolytic Disorders: General Considerations G. Richard Lee Chapter 41. Hereditary Spherocytosis and Other Anemias Due to Abnormalities of the Red Cell Membrane Bertil E. Glader and John N. Lukens Chapter 42. Hereditary Hemolytic Anemias Associated with Abnormalities of Erythrocyte Glycolysis and Nucleotide Metabolism Bertil E. Glader and John N. Lukens Chapter 43. Glucose-6-Phosphate Dehydrogenase Deficiency and Related Disorders of Hexose Monophosphate Shunt and Glutathione Metabolism Bertil E. Glader and John N. Lukens Chapter 44. Mechanisms of Immune Destruction of Erythrocytes Charles J. Parker and John Foerster Chapter 45. Alloimmune Hemolytic Disease of the Fetus and Newborn John M. Bowman Chapter 46. Autoimmune Hemolytic Anemias Anne T. Thomas Chapter 47. Paroxysmal Nocturnal Hemoglobinuria Charles J. Parker and G. Richard Lee Chapter 48. Acquired Hemolytic Anemias Resulting from Direct Effects of Infectious, Chemical, or Physical Agents G. Richard Lee Chapter 49. Red Cell Fragmentation Syndromes John Foerster Section 5. Hereditary Disorders of Hemoglobin Structure and Synthesis Chapter 50. The Abnormal Hemoglobins: General Principles John N. Lukens Chapter 51. Sickle Cell Anemia and Other Sickling Syndromes Winfred C. Wang and John N. Lukens Chapter 52. Unstable Hemoglobin Disease John N. Lukens and G. Richard Lee Chapter 53. The Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis John N. Lukens Section 6. Other Disorders Associated With Anemia Chapter 54. Pancytopenia, Aplastic Anemia, and Pure Red Cell Aplasia Darryl M. Williams Chapter 55. Acute Post–Hemorrhagic Anemia G. Richard Lee Chapter 56. Congenital Dyserythropoietic Anemias G. Richard Lee Chapter 57. The Anemias Associated with Renal Disease, Liver Disease, Endocrine Disease, and Pregnancy G. Richard Lee Chapter 58. Anemias Unique to Infants and Young Children Jeffrey D. Hord and John N. Lukens Section 7. Erythrocytosis Chapter 59. Polycythemia: Erythrocytosis Robert T. Means, Jr. PART V. DISORDERS OF HEMOSTASIS AND COAGULATION Section 1. Introduction Chapter 60. The Diagnostic Approach to the Bleeding Disorders George M. Rodgers and Thomas C. Bithell Section 2. Thrombocytopenia Chapter 61. Thrombocytopenia: Pathophysiology and Classification Shirley Parker Levine Chapter 62. Thrombocytopenia Caused by Immunologic Platelet Destruction Shirley Parker Levine Chapter 63. Thrombotic Thrombocytopenic Purpura and Other Forms of Nonimmunologic Platelet Destruction Shirley Parker Levine Chapter 64. Miscellaneous Causes of Thrombocytopenia Shirley Parker Levine Section 3. Other Disorders of Primary Hemostasis Chapter 65. Bleeding Disorders Caused by Vascular Abnormalities Matthew M. Rees and George M. Rodgers Chapter 66. Thrombocytosis Shirley Parker Levine Chapter 67. Qualitative Disorders of Platelet Function Shirley Parker Levine Section 4. Coagulation Disorders Chapter 68. Inherited Coagulation Disorders George M. Rodgers and Charles S. Greenberg Chapter 69. Acquired Coagulation Disorders Alan B.M. Grosset and George M. Rodgers Section 5. Thrombosis Chapter 70. Thrombosis and Antithrombotic Therapy George M. Rodgers PART VI. NONMALIGNANT DISORDERS OF LEUKOCYTES, THE SPLEEN, AND/OR IMMUNOGLOBINS Chapter 71. Diagnostic Approach to Malignant and Nonmalignant Disorders of the Hematopoietic-Lymphoid System Thomas L. McCurley and John P. Greer Chapter 72. Variations of Leukocytes in Disease James C. Gay and John W. Athens Chapter 73. Neutropenia Raymond G. Watts Chapter 74. Qualitative Disorders of Leukocytes Keith M. Skubitz Chapter 75. Abnormalities of the Monocyte-Macrophage System—The Lysosomal Storage Diseases Margaret M. McGovern and Robert J. Desnick Chapter 76. Langerhans Cell Histiocytosis H. Stacy Nicholson and John N. Lukens Chapter 77. Infectious Mononucleosis John Foerster Chapter 78. Hematologic Aspects of Acquired Immunodeficiency Disease Robert L. Janco Chapter 79. Disorders of the Spleen William C. Chapman and Martin Newman PART VII. HEMATOLOGIC MALIGNANCIES Section 1. General Aspects Chapter 80. The Hematopoietic- Lymphoid Neoplasms John B. Cousar, Charles L. Sawyers, Stephan W. Morris and Martin u Kuefer Chapter 81. Complications of Hematopoietic Neoplasms Edward R. Arrowsmith, John P. Greer, and William R. Macon Chapter 82. Principles and Pharmacology of Chemotherapy Kenneth R. Hande Chapter 83. Supportive Care in Hematologic Malignancies Asha Kallianpur Chapter 84. Immunotherapy Stanford J. Stewart Chapter 85. Gene Therapy for Hematologic Disorders, HIV Infection, and Cancer John F. Tisdale, Cynthia E. Dunbar, and Stacey A. Goodman Section 2. The Acute Leukemias Chapter 86. Classification and Differentiation of the Acute Leukemias Marsha C. Kinney and John N. Lukens Chapter 87. Acute Lymphocytic Leukemia James A. Whitlock and Paul S. Gaynon Chapter 88. Acute Myelogenous Leukemia John P. Greer, Maria R. Baer, and Marsha C. Kinney Chapter 89. The Myelodysplastic Syndromes Alan F. List and Donald C. Doll Section 3. Myeloproliferative Disorders Chapter 90. Chronic Myeloid Leukemia Richard S. Larson and Steven N. Wolff Chapter 91. Polycythemia Vera Robert T. Means, Jr Chapter 92. Myelofibrosis Douglas A. Clark and Wilbur L. Williams Section 4. Lymphoproliferative Disorders Chapter 93. Chronic Lymphocytic Leukemia James B. Johnston Chapter 94. Hairy-Cell Leukemia James B. Johnston Chapter 95. Non-Hodgkin Lymphomas John P. Greer, William R. Macon, and Thomas L. McCurley Chapter 96. Hodgkin Disease Richard S. Stein Chapter 97. Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome John A. Zic, Kevin E. Salhany, John P. Greer, and Lloyd E. King, Jr. Section 5. Plasma Cell Dyscrasias Chapter 98. Plasma Cell Dyscrasias: General Considerations John Foerster Chapter 99. Multiple Myeloma John Foerster and Frixos Paraskevas Chapter 100. Waldenström Macroglobulinemia John Foerster Chapter 101. Heavy Chain Diseases John Foerster Chapter 102. Amyloidosis John Foerster Chapter 103. Cryoglobulins and Cryoglobulinemia John Foerster APPENDICES Appendix A. Normal Blood and Bone Marrow Values in Humans Sherrie L. Perkins Appendix B. Comparative Hematology Harvey A. Ragan List of Color Plates