Insulin resistance : the metabolic syndrome X

CONTENTS Preface........................................................................................................ v Contributors .............................................................................................. ix Part I Genetic and Environmental Factors Affecting Insulin Action 1 Genetics of Insulin Resistance.......................................................... 3 Michael P. Stern and Braxton D. Mitchell 2 Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes ...................................................... 19 Paul M. McKeigue 3 Fetal Effects on Insulin Resistance and Glucose Tolerance .......... 35 Paul M. McKeigue 4 Obesity and Insulin Resistance: Epidemiologic, Metabolic, and Molecular Aspects ................... 51 Jean-Pierre Després and André Marette 5 The Role of Body Fat Distribution in Insulin Resistance .............. 83 Abhimanyu Garg 6 Physical Activity and Insulin Resistance in Man .......................... 97 Flemming Dela, Kári Mikines, and Henrik Galbo 7 Insulin Resistance in Smokers and Other Long-Term Users of Nicotine ................................................................................ 121 Björn Eliasson and Ulf Smith Part II Pathophysiology of Insulin Resistance 8 Insulin Resistance and Inhibitors of Insulin Receptor Tyrosine Kinase ........................................................................ 139 Jack F.Youngren, Ira D. Goldfine, Vincenzo Trischitta, and Betty A. Maddux 9 NMR Studies on the Mechanism of Insulin Resistance .............. 159 Gianluca Perseghin, Kitt Falk Petersen, and Gerald I. Shulman 10 Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms ................................................................ 179 Lawrence J. Mandarino 11 The Role of the Liver in Insulin Action and Resistance .............. 197 Jerry Radziuk and Susan Pye 12 The Pathophysiological Consequences of Adipose Tissue Insulin Resistance ..................................................................... 233 Gerald M. Reaven vii 13 Insulin Action and Endothelial Function ..................................... 247 Alain D. Baron and Michael J. Quon Part III Clinical Syndromes Associated with Insulin Resistance 14 Insulin Resistance and Dyslipidemia: Implications for Coronary Heart Disease Risk ....................... 267 Ami Laws 15 Insulin Resistance and Blood Pressure......................................... 281 Ele Ferrannini 16 Microalbuminuria and Insulin Resistance .................................... 309 Jeannie Yip and Roberto Trevisan 17 PAI-1, Obesity, and Insulin Resistance ........................................ 317 Irène Juhan-Vague, Marie-Christine Alessi, and Pierre E. Morange 18 Insulin Resistance and Cardiovascular Disease ........................... 333 Aaron R. Folsom 19 Insulin Resistance Effects on Sex Hormones and Ovulation in the Polycystic Ovary Syndrome........................................... 347 John E. Nestler Index....................................................................................................... 367