Molecular analysis of cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jacqueline Boultwood; Carrie Fidler
- ناشر : Totowa, N.J. : Humana Press
- چاپ و سال / کشور: 2002
- شابک / ISBN : 9780896036222
Description
Molecular analysis of cancer. An overview -- Detection of chromosome abnormalities in leukemia using fluorescence in situ hybridization -- Spectral karyotyping in cancer cytogenetics -- Comparative genomic hybridization analysis -- Detection of chromosomal deletions by microsatellite analysis -- Detection and quantification of leukemia-specific rearrangements -- Detection of t(2;5)(p23;q35) translocation by long-range PCR of genomic DNA -- Use of DNA fingerprinting to detect genetic rearrangements in human cancer -- Mutation analysis of large genomic regions in tumor DNA using single-strand conformation polymorphism. Lessons from the ATM gene -- Mutational analysis of oncogenes and tumor suppressor genes in human cancer using denaturing gradient gel electrophoresis -- Detection of mutations in human cancer using nonisotopic RNase cleavage assay -- Mutational analysis of the neurofibromatosis type 1 gene in childhood myelodysplastic syndromes using a protein truncation assay -- Mutation analysis of cancer using automated sequencing -- Detection of differentially expressed genes in cancer using differential display -- Genomewide gene expression analysis using cDNA microarrays -- Gene expression profiling in cancer using cDNA microarrays -- Wilms tumor gene WT1 as a tumor marker for leukemic blast cells and its role in leukemogenesis -- Detection of aberrant methylation of the p15INK4B gene promoter -- Clonality studies in cancer based on X chromosome inactivation phenomenon -- Telomere length changes in human cancer -- Measurement of telomerase activity in human hematopoietic cells and neoplastic disorders
