Preclinical drug development, 2nd ed
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mark C Rogge; David R Taft
- ناشر : New York : Informa Healthcare,
- چاپ و سال / کشور: 2010
- شابک / ISBN : 9781420084726
Description
The scope of preclinical drug development : an introduction and framework / Mark C. Rogge -- Lead molecule selection : pharmaceutical profiling and toxicity assessments / P.L. Bullock -- Interspecies differences in physiology and pharmacology : extrapolating preclinical data to human populations / M.N. Martinez -- Pharmacokinetics/ADME of small molecules / A.D. Ajavon and David R. Taft -- Pharmacokinetics/ADME of large molecules / R. Braeckman -- Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / P.L. Bonate and P. Vicini -- Formulation and production strategies for enhancing bioavailability of poorly absorbed drugs / A.B. Watts and R.O. Williams III -- Transporters involved in drug disposition, toxicity, and efficacy / C.Q. Xia and G.T. Miwa -- Toxicity evaluations, ICH guidelines, and current practice / J.L. Larson -- Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice -- Utilizing the preclinical database to support clinical drug development / H. Lee.
The scope of preclinical drug development : an introduction and framework / Mark C. Rogge -- Lead molecule selection : pharmaceutical profiling and toxicity assessments / P.L. Bullock -- Interspecies differences in physiology and pharmacology : extrapolating preclinical data to human populations / M.N. Martinez -- Pharmacokinetics/ADME of small molecules / A.D. Ajavon and David R. Taft -- Pharmacokinetics/ADME of large molecules / R. Braeckman -- Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / P.L. Bonate and P. Vicini -- Formulation and production strategies for enhancing bioavailability of poorly absorbed drugs / A.B. Watts and R.O. Williams III -- Transporters involved in drug disposition, toxicity, and efficacy / C.Q. Xia and G.T. Miwa -- Toxicity evaluations, ICH guidelines, and current practice / J.L. Larson -- Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice -- Utilizing the preclinical database to support clinical drug development / H. Lee.
