Folding for the synapse

1 Folding for the Synapse............................................................................. 1 Andreas Wyttenbach and Vincent O’Connor Part I The Regulation of Protein (mis)folding, Aggregation and Degradation of Proteins by Molecular Chaperones 2 Protein Aggregation: Opposing Effects of Chaperones and Crowding............................................................................................. 9 R. John Ellis 3 Molecular Chaperones as Facilitators of Protein Degradation............. 35 Jörg Höhfeld, Nikolaus Dick, and Verena Arndt 4 The Small Heat-Shock Proteins: Cellular Functions and Mutations Causing Neurodegeneration............................................ 49 C. d’Ydewalle, J. Krishnan, V. Timmerman, and L. Van Den Bosch Part II The� Making� of the Synapse: Transport of Proteins, Vesicles and Organelles 5 Keeping it Together. Axonal Transport to the Synapse and the Effects of Molecular Chaperones in Health and Disease................................................................................ 81 Christopher Sinadinos and Amrit Mudher 6 Mechanisms of Neuronal Mitochondrial Transport............................... 105 F. Anne Stephenson and Kieran Brickley Part III Chaperone Modalities and Homeostatic Mechanisms in the Synaptic Compartment 7 Molecular Chaperones in the Mammalian Brain: Regional Distribution, Cellular Compartmentalization and Synaptic Interactions....................................................................... 123 Andreas Wyttenbach, Shmma Quraishe, Joanne Bailey, and Vincent O’Connor 8 Cysteine-String Protein’s Role at Synapses........................................... 145 Konrad E. Zinsmaier and Mays Imad 9 The Role of Protein SUMOylation in Neuronal Function.................... 177 Kevin A. Wilkinson and Jeremy M. Henley 10 The Ubiquitin–Proteasome System in Synapses................................... 201 Suzanne Tydlacka, Shi-Hua Li, and Xiao-Jiang Li Part IV Chronic Neurodegeneration Associated with Protein Misfolding and Synaptic Dysfunction 11 VAPB Aggregates and Neurodegeneration............................................ 215 P. Skehel 12 Synaptic Dysfunction in Huntington’s Disease..................................... 233 Dervila Glynn and A. Jennifer Morton 13 Synaptic Dysfunction in Parkinson’s Disease: From Protein Misfolding to Functional Alterations............................. 257 Tiago Fleming Outeiro and Luísa Vaqueiro Lopes 14 Synapses and Alzheimers’s Disease: Effect of Immunotherapy?...................................................................... 269 Nathan C. Denham, James A.R. Nicoll, and Delphine Boche 15 Prion Protein Misfolding at the Synapse............................................... 289 Zuzana Šišková, V. Hugh Perry, and Ayodeji A. Asuni Index.................................................................................................................. 313 Part III Chaperone Modalities and Homeostatic Mechanisms in the Synaptic Compartment 7 Molecular Chaperones in the Mammalian Brain: Regional Distribution, Cellular Compartmentalization and Synaptic Interactions....................................................................... 123 Andreas Wyttenbach, Shmma Quraishe, Joanne Bailey, and Vincent O’Connor 8 Cysteine-String Protein’s Role at Synapses........................................... 145 Konrad E. Zinsmaier and Mays Imad 9 The Role of Protein SUMOylation in Neuronal Function.................... 177 Kevin A. Wilkinson and Jeremy M. Henley 10 The Ubiquitin–Proteasome System in Synapses................................... 201 Suzanne Tydlacka, Shi-Hua Li, and Xiao-Jiang Li Part IV Chronic Neurodegeneration Associated with Protein Misfolding and Synaptic Dysfunction 11 VAPB Aggregates and Neurodegeneration............................................ 215 P. Skehel 12 Synaptic Dysfunction in Huntington’s Disease..................................... 233 Dervila Glynn and A. Jennifer Morton 13 Synaptic Dysfunction in Parkinson’s Disease: From Protein Misfolding to Functional Alterations............................. 257 Tiago Fleming Outeiro and Luísa Vaqueiro Lopes 14 Synapses and Alzheimers’s Disease: Effect of Immunotherapy?...................................................................... 269 Nathan C. Denham, James A.R. Nicoll, and Delphine Boche 15 Prion Protein Misfolding at the Synapse............................................... 289 Zuzana Šišková, V. Hugh Perry, and Ayodeji A. Asuni Index.................................................................................................................. 313