Drug benefits and risks : international textbook of clinical pharmacology,2nd ed

Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Foreword to the Second Edition . . . . . . . . . . . xv Foreword to the First Edition . . . . . . . . . . . . . xvii Preface to the Second Edition . . . . . . . . . . . . . xix Preface to the First Edition . . . . . . . . . . . . . . . xxi Section I General Principles . . . . . . . . . . . . . 1 Part A Medicinals in Society . . . . . . . . . . . . 1 1 The Role of Therapeutic Agents in Modern Medicine . . . . . . . . . . . . . . . . . . . . 3 A Drug Benefits . . . . . . . . . . . . . . . . . . . . . 3 Ronald D. Mann B Drug Risks . . . . . . . . . . . . . . . . . . . . . . . 9 Jerry Avorn 2 Therapeutics as a Science . . . . . . . . . . . . . 15 Marcus M. Reidenberg 3 Pharmacoepidemiology and Drug Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Supornchai Kongpatanakul and Brian L. Strom 4 Economic Evaluation of Pharmaceuticals and Clinical Practice . . . . . . . . . . . . . . . . . 37 Kevin A. Schulman, Henry A. Glick, Daniel Polsky and K.R. John 5 Clinical Pharmacology and Drug Policy 57 Marc Blockman and Peter I. Folb 6 Drug Regulation: History, Present and Future . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Lembit Rägo and Budiono Santoso 7 Medicines in Developing Countries . . . . . 79 Budiono Santoso, Kathleen Holloway, Hans V. Hogerzeil and Valerio Reggi 8 Drug Information . . . . . . . . . . . . . . . . . . . . 99 Ylva Böttiger and Anders Rane 9 Drug Development . . . . . . . . . . . . . . . . . . . 107 Michel Briejer and Peter van Brummelen Part B General Clinical Pharmacology . . . 121 10 Clinical Pharmacokinetics . . . . . . . . . . . . 123 Anthony J. Smith and Sri Suryawati 11 Clinical Pharmacodynamics . . . . . . . . . . . 165 Gunnar Alvan, Gilles Paintaud and Monique Wakelkamp 12 Drug Therapy in Pediatric Patients. . . . . 181 Gregory L. Kearns, John T. Wilson, Kathleen A. Neville and Margaret A. Springer 13 Drug Therapy in Older Persons . . . . . . . . 203 Barry Cusack and James Branahl 14 Adverse Drug Reactions . . . . . . . . . . . . . . 225 Ralph Edwards and Chen Yixin 15 Drug–Drug Interactions . . . . . . . . . . . . . . 247 Karen Baxter, Anne Lee and Ivan H. Stockley 16 Drug Misuse – Harmful Use, Abuse and Dependence . . . . . . . . . . . . . . . . . . . . . 263 Ralph Edwards 17 Clinical Pharmacology of Poisoning . . . . 275 Kenneth Hartigan-Go v Section II Pharmacotherapeutic Products 287 18 Neurohumoral Transmission . . . . . . . . . . 289 Martin Pfaffendorf 19 Autacoids . . . . . . . . . . . . . . . . . . . . . . . . . . . 311 Martin Pfaffendorf 20 Drugs Affecting Cardiovascular and Renal Functions . . . . . . . . . . . . . . . . . . . . . . 323 Pieter A. van Zwieten 21 Drugs Acting on the Central Nervous System . . . . . . . . . . . . . . . . . . . . . . 347 Chris J. van Boxtel 22 Hemopoietic Drugs and Drugs that Affect Coagulation . . . . . . . . . . . . . . . . . . . 367 Chris J. van Boxtel 23 Drugs Affecting Gastrointestinal Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377 Chris J. van Boxtel 24 Hormones and Hormone Antagonists . . . 387 Chris J. van Boxtel 25 Antimicrobial Agents . . . . . . . . . . . . . . . . . 407 Chris J. van Boxtel 26 Analgesics, Antirheumatics and Drugs for the Treatment of Gout . . . . . . . . . . . . . 435 Chris J. van Boxtel 27 Antineoplastic Agents. . . . . . . . . . . . . . . . . 447 Chris J. van Boxtel 28 Drugs Used for Immunomodulation . . . . 465 Chris J. van Boxtel 29 Vitamins . . . . . . . . . . . . . . . . . . . . . . . . . . . . 471 Chris J. van Boxtel 30 Dermatologicals and Miscellaneous Agents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 479 Chris J. van Boxtel Section III Treatment of Health Problems 489 31 Symptomatic Treatment . . . . . . . . . . . . . . 491 Iwan Darmansjah and Inger Hagqvist 32 Emergency Medicine . . . . . . . . . . . . . . . . . 505 Jamie J. Coleman, Kumud K. Kafle and Robin E. Ferner 33 A Treatment and Prophylaxis of Infectious Diseases . . . . . . . . . . . . . . . . 521 Michiel A. van Agtmael, Tran Tinh Hien, Inge C. Gyssens and Henri A. Verbrugh B Treatment of HIV/AIDS and of Tuberculosis . . . . . . . . . . . . . . . . . . . 549 Andrew D. Kambugu, Chris J. van Boxtel and Michiel van Agtmael 34 Cardiovascular and Renal Diseases . . . . . 571 A Pharmacotherapy of Hypertension . . . 571 Yackoob K. Seedat B Treatment of Ischemic Heart Disease . 587 Naoki Matsumoto and Shinichi Kobayashi C Treatment of Heart Failure . . . . . . . . . . 593 Naoki Matsumoto and Shinichi Kobayashi D Pharmacological Treatment of Cardiac Arrhythmias . . . . . . . . . . . . . . . . . . . . . . 599 Hirotsugu Atarashi E Pharmacological Treatment of Renal Diseases . . . . . . . . . . . . . . . . . . . . . . . . . 609 Yackoob K. Seedat 35 Gastrointestinal and Hepatobiliary Disorders. . . . . . . . . . . . . . . . . . . . . . . . . . . . 619 Michael J.S. Langman 36 Pharmacotherapy of Chronic Obstructive Pulmonary Disease and Asthma . . . . . . . 637 Emile F.L. Dubois and Dieter Ukena 37 Disorders of Connective Tissue, Bone and Joints . . . . . . . . . . . . . . . . . . . . . . . . . . . 659 John Darmawan 38 Treatment of Psychiatric Disorders . . . . . 675 David Healy and Nicholas Moore 39 Neurological Diseases . . . . . . . . . . . . . . . . . 685 Stéphane Schück, Philippe H. Robert and Jacques Touchon 40 Drug Use for Malignancies . . . . . . . . . . . . 707 David J. Perez 41 Haematological Disorders . . . . . . . . . . . . . 729 Peter Jacobs and Lucille Wood 42 Endocrine Diseases . . . . . . . . . . . . . . . . . . . 751 Robert Djokomoeljanto, Djoko Wahono Soeatmadji and Julian Davis