Probiotics in pediatric medicine

TABLE OF CONTENTS / ORGANIZATION I Introductory Chapters 1. Basics of GI Physiology and Mucosal Immunology (A Fasano) This introductory chapter will provide an overview of the gastrointestinal physiology and mucosal immunity as it relates to the gut with its microflora and its role in the overall health of the child. 2. Basics of Gut Microflora (G Tannock) This chapter will cover the significance of microflora and the traditional and molecular advances in identifying gut microflora. 3. Role of Microflora in Disease (M. Relman). The focus of this chapter is to review the role of microflora in gastrointestinal disorders with a focus on inflammatory bowel disease and irritable bowel syndrome. A review of the role of microflora in non-gastrointestinal disease such as atopic disorders will be included. 4. Probiotics 101 (WA Walker). This chapter will provide the history of probiotic use and the basics for probiotic concepts as it relates to children. 5. Mechanism of Action of Probiotics (B Polk). This chapter will review the basic research pertaining to the mechanism of action of probiotics as evidence by cellular/molecular studies as well as animal studies. 6. Safety of Probiotics (D Mack). The safety of the different types and forms of probiotics will be reviewed with a focus on children. Michail, Probiotics--p. 4 II Infant Health and Probiotics 7. Neonatal and Infant Microflora (JI Gordon) This chapter will identify the development of microflora in the newborn infant and the factors that affect the composition of microflora such as breast feeding versus formula feeding, age of infant and child, mode of child delivery etc! 8. Probiotics in Infant Dietetics (Agostoni). This chapter will review the evidence, or lack thereof, to support the benefit of adding probiotics to infant formulas or infant foods. 9. Probiotics and Nectrotizing Enterocolits (Zvi Weizman). The focus of this chapter will be the role of probiotics and prevention or treatment of necrotizing enterocolitis. III Pediatric GI and Related Diseases - Is There a Role for Probiotics? 10. Irritable Bowel Disease (S Michail). A review of the literature with regards to irritable bowel syndrome will be presented in this chapter. Pediatric data will be reviewed. 11. Infectious Diarrhea (G Fuchs) The role of probiotics in treating and preventing infectious diarrhea in pediatric patients will be covered in this chapter. 12. Crohn's Disease (A Bousvaros) The role of probiotics in treatment and prevention of relapse of Crohn's disease will be reviewed in this chapter. Pediatric data will be discussed as well. 13. Ulcerative Colitis (PM Fedorak) The role of probiotics in treatment and prevention of relapse of ulcerative colitis will be reviewed in this chapter. Any pediatric data will be reviewed. 14. Pouchitis (P Gionchetti) The role of probiotics in prevention and treatment of pouchits will be reviewed in this chapter. Pediatric data will be discussed as well. 15. Antibiotic-associated Diarrhea and Clostridium difficile Infection (H Szajewska). The role of probiotics and treatment and prevention of these disorders with review of the evidence and meta-analysis will be discussed in this chapter. 16. Probiotics in the Immune-compromised Host (T Poussa). This chapter will review the published studies related to the use of probiotics in various disorders affecting the host immune response and immunocompromised states. Michail, Probiotics--p. 5 17. H. Pylori Infection (PM Sherman). Studies related to role of probiotics in H-pylori infection will be discussed in this chapter. 18. Allergy (E Isolauri). The role of probiotics in treatment and prevention of pediatric allergy will be reviewed in this chapter. 19. Asthma (E Isolauri). This chapter will focus on the role of probiotics in the treatment and/or prevention of asthma. 20. Miscellaneous Disorders (S Michail). An overall review of the role of probiotics in miscellaneous disorders such as constipation, Traveler's diarrhea, urogenital infections, etc! will be covered in this chapter. IV Selected, Related Topics 21. Probiotics in Foods and Supplements (S Czinn). This chapter will provide a practical overview of the different probiotic preparations available with a focus on the United States. 22. Prebiotics and Synbiotics (Glenn Gibson). This chapter will discuss the definition and use of prebiotics and synbiotics as they relate to pediatric diseases. 23. Future Probiotic Perspectives (E Quigley). This chapter will focus on where probiotics will be heading in the future with potential new innovations and concepts. The use of probiotics as vehicles for immune-modulation and vectors for delivery of drugs directly to the intestinal mucosa are a few of amazing future topics. Alternative author will be Fergus Shanahan. Appendices x. List of related websites, books and Journals xx. List of probiotic products in the US market Notes on Content / Organization: Innovative organization of information: Each chapter will introduce the concept of the following chapter with a natural flow of information. In addition, each chapter will have a few bullets at the beginning highlighting the importance and objective of the individual chapter. At the conclusion of each chapter, a summary will be written to capture the important content. Michail, Probiotics--p. 6 Superior approach compared to that of the competition: The contents of the proposed book with a focus on the clinical aspects of probiotic use and a further focus on pediatric patients will be superior to that of competition. Chapter organization as described will be superior to that of competition as well.