SiRNA and miRNA gene silencing : from bench to bedside,v. 487.

SiRNA and miRNA gene silencing : from bench to bedside,v. 487.

  • نوع فایل : کتاب
  • زبان : انگلیسی
  • مؤلف : Mouldy Sioud
  • ناشر : New York, NY : Humana Press ; London : Springer [distributor]
  • چاپ و سال / کشور: 2009
  • شابک / ISBN : 9781603275460

Description

Methods for selecting effective siRNA sequences by using statistical and clustering techniques / Shigeru Takasaki -- Deciphering the code of innate immunity recognition of siRNAs / Mouldy Sioud -- Targeted delivery of anitsense oligonucleotides and siRNAs into mammalian cells / Mouldy Sioud -- Local and systemic delivery of siRNAs for oligonucleotide therapy / Fumitaka Takeshita ... [et al.] -- Imaging of siRNA delivery and silencing / Anna Moore and Zdravka Medarova -- Recent advances in magnetofection and its potential to deliver siRNAs in vitro / Olga Mykhaylyk ... [et al.] -- In vitro and in vivo gene silencing by TransKingdom RNAi (tkRNAi) / Shuanglin Xiang ... [et al.] -- Bacterial delivery of siRNAs : a new approach to solid tumor therapy / De-Qi Xu ... [et al.] -- The therapeutic potential of LNA-modified siRNAs : reduction of off-target effects by chemical modification of the siRNA sequence / Kees Fluiter, Olaf R.F. Mook, and Frank Baas -- pSM155 and pSM30 vectors for miRNA and shRNA expression / Junzhu Wu, Akua N. Bonsra, and Guangwei Du -- Targeting oncogenes with siRNAs / Olaf Heidenreich -- Targeting stromal-cancer cell interactions with siRNAs / Seyedhossein Aharinejad ... [et al.] -- Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor, and matrix metalloproteinases / Christopher S. Gondi and Jasti S. Rao -- Silencing of HIF-1[alpha] by RNA interference in human glioma cells in vitro and in vivo / David L. Gillespie ... [et al.] -- RNA interference-mediated validation of genes involved in telomere maintenance and evasion of apoptosis as cancer therapeutic targets / Marco Folini, Marzia Pennati, and Nadia Zaffaroni -- Treating respiratory viral diseases with chemically modified, second generaton intranasal siRNAs/ Sailen Barik -- Progress in the therapeutic applications of siRNAs against HIV-1 / Miguel Angel Martínez -- Protein components of the microRNA pathway and human diseases / Marjorie P. Perron and Patrick Provost -- Intron-mediated RNA interference and microRNA biogenesis / Shao-Yao Ying and Shi-Lung Lin -- Emergence of a complex relationship between HIV-1 and the microRNA pathway / Dominique L. Ouellet ... [et al.] -- Synthetic microRNA targeting glioma-associated antigen-1 protein / Naotake Tsuda ... [et al.] -- Therapeutic targeting of gene expression by siRNAs directed against BCR-ABL transcripts in a patient with Imatinib-resistant chronic myeloid leukemia / Michael Koldehoff and Ahmet H. Elmaagacli.
In this easy-to-use and up-to-date volume, expert researchers explore the most recent advances in siRNA design, expression, delivery, in vivo imaging, and methods. The aim is to minimize siRNA's unwanted effects and promote successful use in patients.
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