Brain hypoxia and ischemia : with special emphasis on development

Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Part I Ion Channels, Transporters and Excitotoxicity 1 Regulation of Vulnerability to NMDA Excitotoxicity During Postnatal Maturation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Jeremy D. Marks 2 Acidosis, Acid-Sensing Ion Channels, and Glutamate Receptor-Independent Neuronal Injury . . . . . . . . . . . . . . . . . . . . . . . . . 25 Zhigang Xiong 3 Brain Ischemia and Neuronal Excitability . . . . . . . . . . . . . . . . . . . . . . . 43 Ping Deng and Zao C. Xu 4 Critical Roles of the Na+/K+-ATPase in Apoptosis and CNS Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 Adrian Sproul, Xin Zhou, and Shan Ping Yu 5 Emerging Role of Water Channels in Regulating Cellular Volume During Oxygen Deprivation and Cell Death . . . . . . . 79 Thomas James Younts and Francis “Monty” Hughes, Jr. 6 A Zinc–Potassium Continuum in Neuronal Apoptosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 Patrick Redman, Megan Knoch, and Elias Aizenman 7 Mitochondrial Ion Channels in Ischemic Brain . . . . . . . . . . . . . . . . . . . 117 Part II Reactive Oxygen Species, and Gene Expression to Behavior 8 Perinatal Panencephalopathy in Premature Infants: Is It Due to Hypoxia-Ischemia? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 Hannah C. Kinney and Joseph J. Volpe 9 Effects of Intermittent Hypoxia on Neurological Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 David Gozal 10 Brainstem Sensitivity to Hypoxia and Ischemia . . . . . . . . . . . . . . . . . . 213 Joseph C. LaManna, Paola Pichiule, Kui Xu, and Juan Carlos Chávez 11 Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia . . . . . . . . . 225 Zezong Gu, Jiankun Cui, and Stuart A. Lipton 12 Oxidative Stress in Hypoxic-Ischemic Brain Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239 Laura L. Dugan, M. Margarita Behrens, and Sameh S. Ali 13 Postnatal Hypoxia and the Developing Brain: Cellular and Molecular Mechanisms of Injury. . . . . . . . . . . . . . . . . . . 255 Robert M. Douglas 14 Hypoxia-Inducible Factor 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277 Gregg L. Semenza 15 Transcriptional Response to Hypoxia in Developing Brain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 Dan Zhou 16 Acute Stroke Therapy: Highlighting the Ischemic Penumbra. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307 Hang Yao 17 Genes and Survival to Low O2 Environment: Potential Insights from Drosophila. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 Gabriel G. Haddad Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 335