Stem cells and cancer

Part I Introduction to Cancer Stem Cells 1 The Cancer Stem Cell Hypothesis .................................................................. 3 Kimberly E. Foreman, Paola Rizzo, Clodia Osipo, and Lucio Miele 2 Tumor Stem Cells and Malignant Cells, One and the Same ........................... 15 Beverly A. Teicher Part II The Stem Cell Niche 3 Mesenchymal Stem Cells in Tumor Stroma ................................................... 29 Nicholas J. Sullivan and Brett M. Hall Part III Molecular Pathways and Gene Expression 4 Wnt Signaling in Cancer: From Embryogenesis to Stem Cell Self-Renewal .............................................................................. 39 Adam Yagui-Beltrán, Biao He, and David M. Jablons 5 PTEN in Hematopoietic and Intestinal Stem Cells and Cancer ...................... 59 Jason T. Ross, David H. Scoville, Xi He, and Linheng Li 6 Transcription Factors in Cancer Stem Cells of the Hematopoietic Lineage ......................................................................... 75 Steffen Koschmieder and Daniel. G Tenen 7 Stem Cell Chromatin Patterns and DNA Hypermethylation .......................... 85 Joyce E. Ohm and Stephen B. Baylin 8 Plasticity Underlying Multipotent Tumor Stem Cells .................................... 99 Lynne-Marie Postovit, Naira V. Margaryan, Elisabeth A. Seftor, Luigi Strizzi, Richard E.B. Seftor, and Mary J.C. Hendrix Part IV Cancer Stem Cells in Solid Tumors 9 Glioma Stem Cells in the Context of Oncogenesis ......................................... 115 Johan Bengzon, Elisabet Englund, Leif G. Salford, and Xiaolong Fan viii Contents 10 Mouse Mammary Tumor Virus: Stem Cells and Mammary Cancer .............. 127 Gilbert H. Smith 11 Tumor Dormancy, Metastasis, and Cancer Stem Cells ................................... 141 Alysha K. Croker, Jason L. Townson, Alison L. Allan, and Ann F. Chambers 12 Cancer Stem Cells: Gastrointestinal Cancers ................................................. 155 Hideshi Ishii, Naotsugu Haraguchi, Keisuke Ieta, Koshi Mimori, and Masaki Mori 13 Cancer Stem Cells: Hepatocellular Carcinoma ............................................... 165 Thomas Shupe and Bryon E. Petersen 14 Cancer Stem Cells: Lung Cancer .................................................................... 177 Jaclyn Y. Hung 15 Cancer Stem Cells: Pancreatic Cancer ............................................................ 185 Joseph Dosch, Cheong Jun Lee, and Diane M. Simeone 16 Prostate Stem Cells and Cancer in Animals ................................................... 199 Alexander Yu. Nikitin, Melia G. Nafus, Zongxiang Zhou, Chun-Peng Liao, and Pradip Roy-Burman 17 Prostate Cancer Stem/Progenitor Cells ........................................................... 217 Sofia Honorio, Hangwen Li, and Dean G. Tang 18 Adult Prostate Epithelium Renewal, Stem Cells and Cancer ......................... 231 Chiara Grisanzio and Sabina Signoretti 19 Stem Cells, Angiogenesis, and Neurogenesis in Tumors ............................... 247 Judith A. Varner Part V Targeting Cancer Stem Cells with Therapy 20 Implications of Cancer Stem Cells for Cancer Therapy ................................. 255 Liang Cheng, Shaobo Zhang, Darrell D. Davidson, Rodolfo Montironi, and Antonio Lopez-Beltran 21 Targeting Leukemic Stem Cells ...................................................................... 263 Angelika M. Burger 22 Targeting Brain Cancer Stem Cells in the Clinic ............................................ 275 Gentao Liu, Keith L. Black, and John S. Yu 23 Critical Roles of Tumorigenic and Migrating Cancer Stem/Progenitor Cells in Cancer Progression and their Therapeutic Implications ................................................................................ 287 Murielle Mimeault and Surinder K. Batra Contents ix 24 Therapeutic Index and the Cancer Stem Cell Paradigm ................................. 309 Vera S. Donnenberg and Albert D. Donnenberg