Asthma : modern therapeutic targets

FIRST LINE ANTI-INFLAMMATORY AND BRONCHODILATOR DRUGS; 1. Novel mechanistic aspects of GCS in relation to asthma therapy. I Adcock; 2. Benefit-risk of long-acting [beta]-adrenergic and ultra long-acting [beta]-adrenergic agonists. M Cazzola; 3. Non-bronchodilator activities of beta2-agonists: enhanced efficacy in the management of asthma? H Hanania; 4. The pros and cons of combination therapy. J Lotvall; 5. Role of PDE4 in asthma. G Currie; AUTOCOIDS AND THEIR RECEPTORS IN AIRWAY DISEASES; 6. Anti-cholinergics in asthma? C Virchow; 7. Controversies on antileukotrienes. S Salvi; 8. Adenosine receptors: novel molecular targets in asthma. D Zeng; 9. TGF-beta: its role in asthma and therapeutic potential. R McAnulty; 10. Transcription factors in asthma: are transcription factors a new target for asthma therapy? J Black; 11. Is IKK2 inhibition a feasible target in asthma? Y Amrani; ENZYME-INHIBITORS; 12. Protease-activated receptors: targets for therapeutic intervention in asthma. M Tunon de Lara; 13. NOS as a therapeutic target in asthma. G Folkerts; 14. Role of metalloprotease inhibitors in asthma. P Thomas; SENSORY NERVES AND SENSORY NEUROPEPTIDES; 15. Sensory neuropeptides as innovative targets in asthma. GF Joos; 16. Rationale for vanilloid receptor 1 agonist-based therapies in asthma. P Geppetti; RECEPTORS IN IMMUNOLOGY; 17. Agents against cytokine synthesis or receptors for asthma. KF Chung; 18. Targeting chemokines in asthma management. L Murray; 19. The CCR3: eotaxin signalling pathway and asthma, J Pease; 20. Putative role of anti-TNF[alpha] drugs in asthma management. I Pavord; 21. The new role of anti-IgE therapy in the treatment of asthma. G D'Amato; MISCELLANEOUS; 22. Life, death and resurrection of allergen immunotherapy in asthma. L Jacobsen, R Polosa; 23. Role of CpG DNA in asthma. J Kline; 24. Putative role of antimicrobial activity in asthma treatment. F Blasi; 25. What is new in the management of acute asthma? G Rodrigo; 26. Rethinking individualized treatment of asthma. FE Hargreave; 27. Determinants of therapeutic response in asthma: cigarette smoking. N Thomson; List of Abbreviations; Index of Papers Reviewed; General Index.