The aptamer handbook : functional oligonucleotides and their applications
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sven Klussmann
- ناشر : Weinheim : Wiley-VCH,
- چاپ و سال / کشور: 2006
- شابک / ISBN : 9783527310593
Description
In vitro selection of functional oligonucleotides and the origins of biochemical activity / James M. Carothers and Jack W. Szostak -- Mathematical models on RNA evolution, simulations in silico, and concepts for in vitro selection / Peter Schuster -- Fitness landscapes, error thresholds, and cofactors in aptamer evolution / Ádam Kun ... [et al.] -- Aptamers to small molecules / Heiko Fickert, Iris G. Fransson, and Ulrich Hahn -- Aptamers to antibiotics / Christina Lorenz and Renée Schroeder -- Aptamers to proteins / Shahid M. Nimjee, Christopher P. Rusconi, and Bruce A. Sullenger -- Aptamers to nucleic acid structures / Jean-Jacques Toulmé ... [et al.] -- Riboswitches : natural metabolite-binding RNAs controlling gene expression / Adam Roth, Rüdiger Welz, and Ronald R. Breaker -- Catalytically active RNA molecules : tools in organic chemistry / Barbara-Sylvia Weigand ... [et al.] -- Deoxyribozymes : catalytically active DNA molecules / Kenny Schlosser, Simon A. McManus, and Yingfu Li -- In vivo and in vitro target validation with nucleic acid aptamers as pharmacological probes / P. Shannon Pendergrast and David M. Epstein -- Intramers for protein function analysis and drug discovery / Michael Famulok and Günter Mayer -- Aptazymes : allosteric ribozymes and deoxyribozymes and biosensors / Scott M. Knudsen and Andrew D. Ellington -- Conversion of aptamers into small-molecule lead compounds / Andreas Jenne -- Aptamers as ligands for affinity chromatography and capillary electrophoresis applications / Eric Peyrin -- Aptamers for in vivo imaging / Sandra Borkowski and Ludger M. Dinkelborg -- Properties of therapeutic aptamers / Sharon T. Cload ... [et al.] -- Spiegelmers for therapeutic applications : use of chiral principles in evolutionary selection techniques / Dirk Eulberg ... [et al.] -- Applications in the clinic : the anti-vegf aptamer / Tony Realini, Eugene W.M. Ng, and Anthony P. Adamis
Concepts and procedures for the generation and application of aptamers (target-binding oligonucleotides) and aptazymes (catalytically active oligonucleotides) are presented in this first comprehensive guide to this emerging field
