Initial UK experience of the levonorgestrel-releasing contraceptive intravaginal ring
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : J. SAHOTA (1), P.M.F. BARNES (1), E. MANSFIELD (1), J.L. BRADLEY (1) and R.J.E. KIRKMAN (2)*
- چاپ و سال / کشور: 2000
Description
A study was performed to establish the tolerance, acceptability and associated e¤cacy of a levonorgestrel-releasing intravaginal ring (IVR) in a sample of British women requiring contraception. This was achieved with an open non-randomized prospective study of 1710 women aged 18^40 years, recruited in 75 centers geographically spread around the UK using an IVR designed to release 20 mg/day of levonorgestrel. Assessments were made at baseline, after 6 weeks, after 3 months and then 3-monthly. After initial insertion of the IVR, it was changed at 3-monthly intervals. A total of 1591 women were eligible for analysis, with 572 available after 12 months and 34 after 24 months of use. Life-table analysis revealed pregnancy rates of 5.1% and 6.5% at 12 months and 24 months, respectively. The IVR was rated as acceptable or very acceptable as a form of contraceptive by 60.7% of women at 12 months. The most common adverse events were menstrual disturbance, headache and vaginal discharge. No signi¢cant pattern of biochemical, hematological, micro- biological or cytological abnormalities was found but vaginal erythematous lesions were noted at some centers. This IVR was found to be a generally well-accepted method of contraception with a failure rate comparable to some other progestogen- only methods. On this basis, further development of hormone-releasing intravaginal rings is justi¢ed.
Advances in Contraception, 1999; 15: 313^324. #2000Kluwer Academic Publishers. Printed in theNetherlands
