Long-lasting remission of type 1 diabetes following treatment with topiramate for generalized seizures
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Alberto M. Davalli , Carla Perego , Franco B. Folli , Emanuele Bosi
- چاپ و سال / کشور: 2011
Description
We report a case of unusually long-lasting remission of type 1 diabetes (T1D). The patient, a Caucasian man, at the age of 43 years developed a ketotic diabetes, classified as type 1 based on clinical presentation and positivity for islet autoantibodies. Shortly after diabetes onset, oral topiramate was added to preexisting valproic acid for generalized seizures and maintained thereafter. Initial intensive insulin treatment was rapidly reduced to low doses (3 Units/day) maintained for a long time and then discontinued at month 55; fasting glucose and glycosylated hemoglobin were basically normalized at 58 months. An oral glucose tolerance test performed at month 53 showed an impaired fasting glucose (6.0 mmol/l) and a value slightly above the threshold for the diagnosis of diabetes at 2 h (11.2 mmol/l). We hypothesize that this unusually prolonged preservation of b-cell function might be ascribed to the concomitant therapy with topiramate, an antiepileptic agent with demonstrated efficacy as antidiabetic in type 2 diabetes (T2D). Topiramate should be further investigated as candidate agent for the preservation of b-cell function also in T1D.
Acta Diabetol DOI 10.1007/s00592-011-0268-y Received: 31 January 2011 / Accepted: 2 February 2011 Springer-Verlag 2011
