Gitelman syndrome complicated with dysglycemia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Alper Azak Bu¨ lent Huddam Gu¨lay Koc¸ak Levent Ortabozkoyun Mehmet Uzel Murat Duranay
- چاپ و سال / کشور: 2011
Description
It has been recently published about the association between low potassium and diabetes development by Chatterjee et al. [1]. Also there is available data suggesting that hypokalemia is associated with high blood glucose [2]. Altered glucose tolerance may be due to a decreased insulin secretion [3]. A 23-year-old man administered to our clinic with fatigue and cramps involving arms and legs. Hypokalemia has been revealed. Serum potassium level was measured as 3.3 mmol/l and magnesium level was 0.6 mmol/l with increased plasma renin activity and aldosterone levels that are 10.8 ng/ml/h (normal range for age: 0.5–5.9 ng/ml/h) and 104 ng/dl (normal range for age: 4–44 ng/dl), respectively, in the absence of hypertension; 24-h urine calcium excretion was revealed as 7 mg/d that is decreased. Doppler ultrasound and angio-computed tomography (CT) of renal arteries were normal. Abdomen CT did not reveal any adrenal mass. Patient did not have severe ataxia, epilepsy, and deafness that are clinical features of EAST syndrome [4]. He did not undergo genetic examination, and the diagnosis is based on clinical features. After establishment of Gitelman syndrome, the patient prescribed spironolactone, potassium, and magnesium chloride per
Received: 20 January 2011 / Accepted: 5 March 2011 Springer-Verlag 2011 Acta Diabetol DOI 10.1007/s00592-011-0277-x
