Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Andrew P. Mizisin Ananda Weerasuriya
- چاپ و سال / کشور: 2010
Description
The endoneurial microenvironment, delimited by the endothelium of endoneurial vessels and a multilayered ensheathing perineurium, is a specialized milieu inte´rieur within which axons, associated Schwann cells and other resident cells of peripheral nerves function. The endothelium and perineurium restricts as well as regulates exchange of material between the endoneurial microenvironment and the surrounding extracellular space and thus is more appropriately described as a blood–nerve interface (BNI) rather than a blood–nerve barrier (BNB). Input to and output from the endoneurial microenvironment occurs via blood–nerve exchange and convective endoneurial fluid flow driven by a proximo-distal hydrostatic pressure gradient. The independent regulation of the endothelial and perineurial components of the BNI during development, aging and in response to trauma is consistent with homeostatic regulation of the endoneurial microenvironment. Pathophysiological alterations of the endoneurium in experimental allergic neuritis (EAN), and diabetic and lead neuropathy are considered to be perturbations of endoneurial homeostasis. The interactions of Schwann cells, axons, macrophages, and mast cells via cell–cell and cell– matrix signaling regulate the permeability of this interface. A greater knowledge of the dynamic nature of tight junctions and the factors that induce and/or modulate these key elements of the BNI will increase our understanding of peripheral nerve disorders as well as stimulate the development of therapeutic strategies to treat these disorders.
Acta Neuropathol (2011) 121:291–312 DOI 10.1007/s00401-010-0783-x Received: 24 September 2010 / Revised: 15 November 2010 / Accepted: 16 November 2010 / Published online: 7 December 2010
