APP involvement in retinogenesis of mice
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Virginie Dinet Na An Giuseppe D. Ciccotosto Julien Bruban Agathe Maoui Shayne A. Bellingham Andrew F. Hill Olav M. Andersen Anders Nykja
- چاپ و سال / کشور: 2010
Description
Very few studies have examined expression and function of amyloid precursor protein (APP) in the retina. We showed that APP mRNA and protein are expressed according to the different waves of retinal differentiation. Depletion of App led to an absence of amacrine cells, a 50% increase in the number of horizontal cells and alteration of the synapses. The retinas of adult APP-/- mice showed only half as many glycinergic amacrine cells as wild-type retinas. We identified Ptf1a, which plays a role in controlling both amacrine and horizontal cell fates, as a downstream effector of APP. The observation of a similar phenotype in sorLA knockout mice, a major regulator of APP processing, suggests that regulation of APP functions via sorLA controls the determination of amacrine and horizontal cell fate. These findings provide novel insights that indicate that APP plays an important role in retinal differentiation.
Acta Neuropathol (2011) 121:351–363 DOI 10.1007/s00401-010-0762-2 Received: 26 August 2010 / Revised: 11 October 2010 / Accepted: 14 October 2010 / Published online: 27 October 2010
