Cholinergic imbalance in the multiple sclerosis hippocampus
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Evert-Jan Kooi Marloes Prins Natasha Bajic Jeroen A. M. Belie¨n Wouter H. Gerritsen Jack van Horssen Eleonora Aronica Anne-Marie van Dam
- چاپ و سال / کشور: 2011
Description
Hippocampal pathology was shown to be extensive in multiple sclerosis (MS) and is associated with memory impairment. In this post-mortem study, we investigated hippocampal tissue from MS and Alzheimer’s disease (AD) patients and compared these to non-neurological controls. By means of biochemical assessment, (immuno)histochemistry and western blot analyses, we detected substantial alterations in the cholinergic neurotransmitter system in the MS hippocampus, which were different from those in AD hippocampus. In MS hippocampus, activity and protein expression of choline acetyltransferase (ChAT), the acetylcholine synthesizing enzyme, was decreased, while the activity and protein expression of acetylcholinesterase (AChE), the acetylcholine degrading enzyme, was found to be unaltered. In contrast, in AD hippocampus both ChAT and AChE enzyme activity and protein expression was decreased. Our findings reveal an MS-specific cholinergic imbalance in the hippocampus, which may be instrumental in terms of future treatment options for memory problems in this disease
Acta Neuropathol DOI 10.1007/s00401-011-0849-4 Received: 20 April 2011 / Revised: 9 June 2011 / Accepted: 9 June 2011
