Long-term open-label response to atomoxetine in adult ADHD:influence of sex, emotional dysregulation, and double-blind response to atomoxetine
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Barrie K. Marchant Fred W. Reimherr Corinne Halls Erika D. Williams Robert E. Strong Douglas Kondo Poonam Soni Reid J. Robison
- چاپ و سال / کشور: 2011
Description
A three-year open-label study of atomoxetine in adults with ADHD followed two multicenter, double-blind trials. In the double-blind trials, female gender and higher levels of emotional symptoms were associated with better outcome. Following a 4-week placebo washout period, 384 (of 536) subjects continued into the open-label study. 61% of subjects entering this open-label study remained after 6 months at an average dose of 100 mg/day. Subjects who had previously responded to double-blind atomoxetine achieved maximum response after 8 weeks of open-label medication, but others continued to improve for 36 weeks. Women improved more (7.7 ± 6.4) than men (6.1 ± 6.4) on the Wender–Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) (P = .007) and the Conners’ Adult ADHD Rating Scale (P = .03). Subjects with emotional dysregulation improved more than others on the WRAADDS (P = .001). Responders ultimately improved approximately 60% in attentional, hyperactive/impulsive, and emotional symptoms. Thirty-nine percent of atomoxetine double-blind non-responders became responders during open-label treatment.
ADHD Atten Def Hyp Disord DOI 10.1007/s12402-011-0054-2 Received: 1 December 2010 / Accepted: 10 March 2011
