High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jun Kang & Jeong Hyun Cho & Cheol Won Suh & Dae Ho Lee & Heung Bum Oh & Yong Hak Sohn & Hyun Sook Chi & Chan Jeong Park & Sung Soo Jang & Kyoo Hyung L
- چاپ و سال / کشور: 2010
Description
We performed a large case–control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBVand HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin’s lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.
Ann Hematol (2011) 90:159–164 DOI 10.1007/s00277-010-1055-5 Received: 25 July 2010 / Accepted: 16 August 2010 / Published online: 7 September 2010
