A study on nm23-H1 expression in diffuse large B-celllymphoma that was treated with CyclOBEAP plus rituximab therapy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Nozomi Niitsu & Jun-ichi Tamaru & Tadashi Yoshino & Naoya Nakamura &Shigeo Nakamura & Kohichi Ohshima & Hirokazu Nakamine & Masataka Okamoto
- چاپ و سال / کشور: 2010
Description
In our previous study on nm23-H1 expression with diffuse large B-cell lymphoma (DLBCL), we found that patients with positive nm23-H1 had significantly poorer prognosis than patients with negative nm23-H1. We examined whether nm23-H1 is a prognostic factor of DLBCL in the rituximab era. The subjects were 101 DLBCL patients who underwent R-CyclOBEAP (rituximab, cyclophosphamide, vincristine, bleomycin, etoposide, doxorubicin, and prednisolone) therapy and in whom markers could be analyzed. We evaluated CD5, CD10, BCL2, BCL6, MUM1, and nm23-H1 expression by immunohistochemistry. Ninety-four DLBCL patients who underwent CyclOBEAP therapy were assumed as historical controls. Among DLBCL patients who underwent CyclOBEAP therapy, BCL2 positivity, MUM1 positivity, nongerminal center B-cell (non-GCB), and nm23-H1 positivity were associated with significantly shorter overall survival (OS) and progression-free survival (PFS). On the other hand, among DLBCL patients who underwent RCyclOBEAP therapy, the 5-year OS rates of the nm23- H1-positive DLBCL (n=32) and nm23-H1-negative DLBCL groups (n=69) were 65% and 97%, respectively (p=0.001), with 5-year PFS rates of 51% and 89%, respectively (p=0.001). In the rituximab era, BCL2, MUM1, and non-GCB were not prognostic factors. We demonstrated that among patients with DLBCL who underwent R-CyclOBEAP therapy, patients with nm23-H1 expression had a significantly poorer prognosis than patients without nm23-H1 expression. These results suggest an important role for nm23-H1 in malignant progression and a potential therapeutic target for DLBCL.
Ann Hematol (2011) 90:185–192 DOI 10.1007/s00277-010-1060-8 Received: 25 June 2010 / Accepted: 16 August 2010 / Published online: 1 September 2010
