Alterations of hemostatic parameters in the early development of allogeneic hematopoietic stem cell transplantation-related complications
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yue Han & Li Zhu & Aining Sun & Xiaoxu Lu & Luping Hu & Lili Zhou & Yongya Ren & Xiaohui Hu & Xiaojin Wu & Zhaoyue Wang & Changgeng Ruan & Depei Wu
- چاپ و سال / کشور: 2011
Description
Thrombotic events are common and potentially fatal complications in patients receiving hematopoietic stem cell transplantation (HSCT). Early diagnosis is crucial but remains controversial. In this study, we investigated the early alterations of hemostatic parameters in allogeneic HSCT recipients and determined their potential diagnostic values in transplantation-related thrombotic complications and other post-HSCTevents. Results from 107 patients with allogeneic HSCTshowed higher levels of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and tissue-plasminogen activator (t-PA) and a lower level of plasma protein C after transplantation. No change was found for prothrombin time, antithrombin III, D-dimer, and activated partial thromboplastin time following HSCT. Transplantation-related complications (TRCs) in HSCT patients were defined as thrombotic (n=8), acute graft-versus-host disease (aGVHD, n=45), and infectious (n=38). All patients with TRCs, especially the patients with thrombotic complications, presented significant increases in the mean and maximum levels of PAI-1 during the observation period. Similarly, a high maximum t-PA level was found in the thrombotic group. In contrast, apparent lower levels of mean and minimum protein C were observed in the TRC patients, especially in the aGVHD group. Therefore, the hemostatic imbalance in the early phase of HSCT, reflecting prothrombotic state and endothelial injury due to the conditioning therapy or TRCs, might be useful in the differential diagnosis of the thrombotic complication from other TRCs.
Ann Hematol DOI 10.1007/s00277-011-1273-5 Received: 11 September 2010 / Accepted: 5 June 2011
