Hodgkin’s lymphoma—long-term outcome: an experience from a tertiary care cancer center in North India
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Prasanth Ganesan & Lalit Kumar & Vinod Raina & Atul Sharma & Sameer Bakhshi & Vishnubhatla Sreenivas & Malini Vijayaraghavan & Sanjay Thulkar
- چاپ و سال / کشور: 2011
Description
Limited information is available from developing countries on long-term outcome of patients with Hodgkinپfs lymphoma (HL). Between January 1998 and December 2005, 262 patients (age .15 years) underwent treatment. Patientsپf median age was 30 years, ranging from 15 to 72 years. Male to female ratio was 2.8:1. B symptoms were present in 64% of patients. Seventy percent of patients had stage III and IV disease. Mixed cellularity (52.3%) was the most common histology followed by nodular sclerosis (38%). ABVD chemotherapy was used in 85% of the patients, and 50% received radiotherapy as consolidation. Following treatment 92% of patients achieved complete response. Five-year freedom from treatment failure (FFTF) and overall survival rate are 78.3% and 86.6%پ}0.02% (95% CI 80.0.93.2%), respectively. Stage at presentation, number of lymph node regions involved (.3 vs .2), presence of B symptoms, and serum albumin (.40 vs <40 g/L) were important determinants of FFTF. In a subset analysis of stage I and II HL patients, presence of bulky disease and pure infradiaphragmatic disease was associated with inferior outcome. On multivariate analysis involvement of three or more number of lymph node regions was a significant predictor of inferior freedom from treatment failure survival (hazard ratio 2.2, p<0.01). Our analysis confirms excellent outcome for patients of Hodgkinپfs lymphoma with results comparable to developed countries.
Ann Hematol DOI 10.1007/s00277-011-1262-8
