Platelet activation and function during eltrombopag treatment in immune thrombocytopenia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Johanna Haselboeck & Ingrid Pabinger & Cihan Ay & Silvia Koder & Simon Panzer
- چاپ و سال / کشور: 2011
Description
We monitored platelet activation by means of Pselectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombopag. Overall, platelet activation and function normalized with increasing platelet counts. However, P-selectin, which was already elevated before treatment, and PMA increased further transiently during the first weeks. The increases in P-selectin and in PMA indicate ongoing platelet activation during the early period of treatment.
Ann Hematol DOI 10.1007/s00277-011-1249-5 Received: 26 January 2011 / Accepted: 27 April 2011
