Effect of dialysis on cerebral blood flow in depressive end-stage renal disease patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hyun-Yeol Nam Sang Heon Song Seong-Jang Kim Ihm Soo Kwak In Joo Kim Soo Bong Lee Dong Won Lee Bum Soo Kim Kyoungjune Pak Yong-Ki Kim
- چاپ و سال / کشور: 2011
Description
Objective The aim of this study was to investigate regional cerebral blood flow (rCBF) changes of end-stage renal disease (ESRD) patients with depressive symptoms during dialysis. Methods Fourteen patients with ESRD underwent Tc-99m ethylcysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) and were evaluated the severity of depressive mood at pre-dialytic period and at least 6 months after dialysis initiation. rCBF was analyzed using statistical parametric mapping (SPM) in brain SPECT image. The responder was defined as a decrease of C25% in Hamilton Depression Rating Scale (HDRS) score from baseline HDRS score. Results Pre-dialysis brain SPECT did not show any rCBF differences between responders and non-responders. The follow-up brain SPECT revealed a significant higher perfusion in left middle temporal gyrus of responder group when compared with non-responder (hemisphere coordinate X, Y, Z; -58, -2, -16, peak Z = 3.36, p = 0.046). In responder, a significant increase in rCBF was found in right parahippocampal gyrus (hemisphere coordinate X, Y, Z; 30, -40, -14, peak Z = 3.51, p = 0.043). In non-responder, there were significant decreases in rCBF in left superior frontal gyrus (hemisphere coordinate X, Y, Z; -22, 30, 42, peak Z = 3.86, p = 0.032) and right orbitofrontal cortex (hemisphere coordinate X, Y, Z; 10, 58, -6, peak Z = 3.81, p = 0.046). Conclusion The present findings showed the characteristic patterns of rCBF changes in depressive ESRD patients having maintenance dialysis. Further investigations in brain blood flow and glucose metabolism are needed to elucidate the effect of dialysis itself and the difference of according to dialysis modality in patients having depression and ESRD.
Ann Nucl Med (2011) 25:165–171 DOI 10.1007/s12149-010-0440-4 Received: 12 August 2010 / Accepted: 8 October 2010 / Published online: 12 January 2011
