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Omission of [15O]CO scan for PET CMRO2 examination using 15O-labelled compounds
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yasuhiro Sasakawa Nobuyuki Kudomi Yuka Yamamoto Toshihide Monden Nobuyuki Kawai Yoshihiro Nishiyama
- چاپ و سال / کشور: 2010
Description
Objective CBF, OEF and CMRO2 provide us important clinical indices and are used for assessing ischemic degree in cerebrovascular disorders. These quantitative images can be measured by PET using 15O-labelled tracers such as C15O, C15O2 and 15O2. To reduce the time of scan, one possibility is to omit the use of CBV data. The present study investigated the influence of fixing the CBV to OEF and CMRO2 values on subjects with and without cerebrovascular disorders. Methods The study consisted of three groups, namely, GROUP-0 (n = 10), GROUP-1 (n = 9), and GROUP-2 (n = 10), corresponding to—without significant disorder, with elevated CBV, and with reduced CBF and elevated OEF, respectively. All subjects received PET examination and using the PET data OEF and CMRO2 images were computed by fixing CBV and with CBV data. The computed OEF and CMRO2 values were compared between the methods. Results The OEF and CMRO2 values obtained by fixing the CBV were around 10% underestimation against that with CBV data. The regression analysis showed that these values were comparable (r = 0.93–0.98, P\0.001). The simulation showed that fixing of the CBV would not derive significant error in either OEF or CMRO2 values, when changed from 0 to 0.08 ml/g. Conclusion This study shows the feasibility of fixing the CBV value for computing OEF and CMRO2 values in the PET examination, suggesting the CO scan could be eliminated.
Ann Nucl Med (2011) 25:189–196 DOI 10.1007/s12149-010-0438-y Received: 15 September 2010 / Accepted: 12 October 2010 / Published online: 16 November 2010
