Limited diagnostic and predictive values of dual-time-point 18F FDG PET/CT for differentiation of incidentally detected thyroid nodules
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Seong-Jang Kim Bo Hyun Kim Yun Kyung Jeon Sang Soo Kim In Joo Kim
- چاپ و سال / کشور: 2011
Description
Objective To assess usefulness of dual-time-point 18F FDG PET/CT to differentiate malignant from benign thyroid nodules and predict the potential factor for malignancy. Methods Fifty patients (age 38–83 years, mean 58 ± 10.6 years) with thyroid nodule were recruited. The 18F FDG PET/CT images were analyzed visually and quantitatively. Results The optimal visual grade of early and delayed images was[grade 3. When SUVmax1 of[2.9 was used as cut off point, the sensitivity and specificity were 55.5 and 63.4%. When SUVmax2 was [3.1, the sensitivity and specificity were 88.8 and 43.9%. When %DSUVmax was B9.09%, the sensitivity and specificity were 33.3 and 87.8%. ROC analyses showed that all indices had similar efficacy without significances. No definite predictor could be found for malignant nodules. Conclusion The dual-time-point 18F FDG PET/CT is not a useful method for differentiating malignant and benign nodules.
Ann Nucl Med (2011) 25:347–353 DOI 10.1007/s12149-011-0468-0 Received: 19 October 2010 / Accepted: 7 January 2011 / Published online: 27 January 2011
