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Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Thorsten Derlin Christian R. Habermann Jasmin D. Hahne Ivayla Apostolova Susanne Klutmann Janos Mester Ralph Buchert
- چاپ و سال / کشور: 2011
Description
Objective Impaired renal function causes both increased and prolonged tracer availability in the blood-pool which might result in increased tracer accumulation in atherosclerotic lesions. Therefore, the aim of this study was to investigate a possible correlation between the intensity of tracer uptake in atherosclerotic lesions and renal function. Methods Data from 50 [18F]-FDG scans were visually evaluated for tracer uptake in vessel wall alterations. Lesions were analyzed semiquantitatively by determining the blood-pool standardized uptake values (SUVblood-pools), maximum SUVs (SUVmaxs), and the target-to-background ratio (TBR). These parameters were tested for correlation with estimated glomerular filtration rate (eGFR), and cardiovascular risk factors. Results Both SUVblood-pools (rs = -0.32, p = 0.03) and SUVmaxs for [18F]-FDG (rs = -0.50, p\0.0001) showed a significant negative correlation with eGFR. TBRs for [18F]-FDG demonstrated a significant positive correlation with eGFRs (rs = 0.21, p = 0.02). Conclusion This study found that both intravascular tracer availability (SUVblood-pool) and intralesional tracer uptake (SUVmax) are influenced by renal function. Calculation of TBR to account for that effect may result in overcorrection in case of [18F]-FDG. Renal insufficiency or subclinical changes in renal function have to be considered as a confounding factor in PET of atherosclerotic lesions
Ann Nucl Med DOI 10.1007/s12149-011-0503-1 Received: 1 April 2011 / Accepted: 24 May 2011
