Control of cardiovascular differentiation by microRNAs
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kisho Ohtani Stefanie Dimmeler
- چاپ و سال / کشور: 2011
Description
MicroRNAs (miRs) are small non-coding RNAs, which control gene expression either by inducing mRNA degradation or by blocking translation, and play a crucial role in tissue homeostasis. In the cardiovascular system, miRs were shown to control cardiac hypertrophy, fibrosis and apoptosis, angiogenesis, and vessel remodeling. In addition, miRs regulate stem cell maintenance and some miRs induced cell fate decisions. This review summarizes the current insights into the control of stem cells and lineage commitment by miRs focusing specifically to the regulation of endothelial, smooth muscle, and cardiac lineage
Basic Res Cardiol (2011) 106:5–11 Received: 14 October 2010 / Revised: 9 November 2010 / Accepted: 30 November 2010 / Published online: 24 December 2010
