NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Alexander Sirker Min Zhang Ajay M. Shah
- چاپ و سال / کشور: 2011
Description
NADPH oxidase family enzymes (or NOXs) are the major sources of reactive oxygen species (ROS) that are implicated in the pathophysiology of many cardiovascular diseases. These enzymes appear to be especially important in the modulation of redox-sensitive signalling pathways that underlie key cellular functions such as growth, differentiation, migration and proliferation. Seven distinct members of the family have been identified of which four (namely NOX1, 2, 4 and 5) may have cardiovascular functions. In this article, we review our current understanding of the roles of NOX enzymes in several common cardiovascular disease states, with a focus on data from genetic studies and clinical data where available.
Basic Res Cardiol (2011) 106:735–747 Received: 22 February 2011 / Revised: 11 April 2011 / Accepted: 28 April 2011 / Published online: 20 May 2011
