CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mizuhiko Terasaki Yasuo Sugita Fumiko Arakawa Yosuke Okada Koichi Ohshima Minoru Shigemori
- چاپ و سال / کشور: 2011
Description
Chemokines are 8- to 12-kDa peptides that function as chemoattractant cytokines involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled, seven-span transmembrane receptors on the plasma membrane of target cells. Chemokine (C-X-C motif) ligand 12 (CXCL12), an alphachemokine that binds to G-protein-coupled chemokine (C-X-C motif) receptor 4 (CXCR4), plays an important and unique role in the regulation of stem/progenitor-cell trafficking. As CXCR4 is expressed on several cancer cells, these CXCR4-positive cancer cells may metastasize to organs that secrete/express CXCL12. Regarding brain tumors, recent data demonstrate that glioma tumor stemlike cells promote tumor angiogenesis and vasculogenesis via the CXCL12/CXCR4 pathway. In addition, CXCL12/ CXCR4 have recently been shown to be expressed in primary central nervous system (PCNS) lymphomas, and a role for chemokines in the pathogenesis of PCNS lymphomas was suggested. This review focuses on current knowledge regarding the biology of the CXCL12/CXCR4 pathway in the context of understanding their potential role in malignant gliomas and PCNS lymphoma development. The CXCL12/CXCR4 interaction as a therapeutic target for malignant brain tumors is also discussed.
Brain Tumor Pathol (2011) 28:89–97 DOI 10.1007/s10014-010-0013-1 Received: 15 November 2010 / Accepted: 15 November 2010 / Published online: 6 January 2011 The Japan Society of Brain Tumor Pathology 2010
