Rhabdoid glioblastoma in a child: case report and literature review
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hiroyuki Momota Kenichiro Iwami Masazumi Fujii Kazuya Motomura Atsushi Natsume Jiro Ogino Tadashi Hasegawa Toshihiko Wakabayashi
- چاپ و سال / کشور: 2011
Description
Rhabdoid glioblastoma is a rare type of glioblastoma characterized by cells resembling rhabdomyoblasts. Several reports have identified its aggressive clinical course and the pathological differences from other primary brain tumors. We report a case of rhabdoid glioblastoma in a 12-year-old boy who presented with headache and harbored a 70-mm solid tumor in the left temporal lobe. The tumor was surgically excised, but early tumor recurrence and leptomeningeal spread developed, and the patient died of the disease 4.9 months after surgery. Histologically, the tumor contained two distinct patterns of glioblastoma and rhabdoid cells with necrosis and hemorrhage. Immunohistochemical analysis revealed that both cells were positive for glial fibrillary acid protein, vimentin, and INI1, which is consistent with the reported diagnosis of rhabdoid glioblastoma. Genetic studies confirmed no loss of the INI1 gene and identified hemizygous deletion of the CDKN2A gene. We review reported cases of rhabdoid glioblastoma and summarize the clinical, radiological, and histological features
Brain Tumor Pathol (2011) 28:65–70 DOI 10.1007/s10014-010-0010-4 Received: 7 September 2010 / Accepted: 18 October 2010 / Published online: 7 January 2011 The Japan Society of Brain Tumor Pathology 2010
