Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and 11C-methionine-, 11C-choline-, and 18F-fluorodeoxyglucose-PET
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Shunsuke Takenaka Jun Shinoda Yoshitaka Asano Tatsuki Aki Kazuhiro Miwa Takeshi Ito Kazutoshi Yokoyama Toru Iwama
- چاپ و سال / کشور: 2011
Description
Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a wellenhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult. The aim of this study was to assess the different metabolic activities between MAID and malignant gliomas by MRS, methionine-PET, choline-PET, and FDG-PET. Six patients with MAID underwent methionine, choline, and FDG-PET, and 4 of the patients also underwent magnetic resonance spectroscopy (MRS). The images obtained from these patients were compared with the corresponding images of 19 anaplastic astrocytomas (AA) and 21 glioblastomas (GBM). The mean choline/creatine ratio of MAID was significantly lower than that of GBM. There were no significant differences in the mean NAA/creatine and lactate/ creatine ratios among these pathologies. The methionine T/N ratio of MAID was significantly lower than those of AA and GBM. The choline T/N ratio of MAID was significantly lower than that of GBM. There were no significant differences in the FDG T/N ratios among these pathologies. These results demonstrate that the metabolic activity of MAID significantly differs in part from that of malignant gliomas. Combined PET and MRS neuroimaging examinations may be useful for differential diagnosis of these pathologies.
Brain Tumor Pathol (2011) 28:229–238 DOI 10.1007/s10014-011-0027-3 Received: 26 January 2011 / Accepted: 21 February 2011 / Published online: 26 March 2011 The Japan Society of Brain Tumor Pathology 2011
