Spindle cell oncocytoma of the adenohypophysis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Alfredo Ernesto Romero-Rojas Mario Alexander Melo-Uribe Paula Alejandra Barajas-Solano Sandra Isabel Chinchilla-Olaya Ligia Ine´s Restrepo Esc
- چاپ و سال / کشور: 2011
Description
Spindle cell oncocytoma of the adenohypophysis (SCO) is defined as spindle to epithelioid cells with oncocytic appearance presenting in the adenohypophysis. In contrast to pituitary adenomas, the SCO does not show immunoreactivity for neuroendocrine markers and pituitary hormones but co-expressed vimentin, S-100 protein, epithelial membrane antigen (EMA), and antimitochondrial antibody MU213-UC clone 131-1. We describe an SCO in an adult, a 42-year-old woman whose magnetic resonance (MR) images documented an intrasellar lesion located in the hypophysis. Histopathological examination showed a tumor composed predominantly of spindle cells. Immunohistochemical studies showed positivity for vimentin, S10, EMA, and antimitochondrial antibody MU213-UC clone 131. Cytokeratin (CK) (AE1/AE3), glial fibrillary acidic protein (GFAP), chromogranin, synaptophysin, PGP9.5, CD57, desmin, D2-40, smooth muscle actin (SMA), Bcl-2, progesterone receptor, and CD34 were negative. Neuropeptides were negative. With electron microscopy, the neoplastic cells appear filled with mitochondria, well-formed desmosomes, but lacked secretory granules. SPO is a rare non-endocrine neoplasm of the adenohypophysis with benign biological behavior corresponding to WHO grade I
Brain Tumor Pathol DOI 10.1007/s10014-011-0051-3Received: 14 March 2011 / Accepted: 17 June 2011 The Japan Society of Brain Tumor Pathology 2011
