Trastuzumab-DM1 (T-DM1) retains all the mechanisms of actionn of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Teemu T. Junttila Guangmin Li Kathryn Parsons Gail Lewis Phillips Mark X. Sliwkowski
- چاپ و سال / کشور: 2010
Description
Trastuzumab (Herceptin) is currently used as a treatment for patients whose breast tumors overexpress HER2/ErbB2. Trastuzumab-DM1 (T-DM1, trastuzumab emtansine) is designed to combine the clinical benefits of trastuzumab with a potent microtubule-disrupting drug, DM1 (a maytansine derivative). Currently T-DM1 is being tested in multiple clinical trials. The mechanisms of action for trastuzumab include inhibition of PI3K/AKT signaling pathway, inhibition of HER-2 shedding and Fcc receptor mediated engagement of immune cells, which may result in antibody-dependent cellular cytotoxicity (ADCC). Here we report that T-DM1 retains the mechanisms of action of unconjugated trastuzumab and is active against lapatinib resistant cell lines and tumors.
Breast Cancer Res Treat (2011) 128:347–356 Received: 15 June 2010 / Accepted: 21 July 2010 / Published online: 21 August 2010 Springer Science+Business Media, LLC. 2010
