Native MAG-1 antibody almost destroys human breast cancer xenografts
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : William G. North Roy H. L. Pang Guohong Gao Vincent A. Memoli Bernard F. Cole
- چاپ و سال / کشور: 2010
Description
native form of mouse monoclonal IgG1 antibody called MAG-1, which recognizes an epitope on provasopressin, has been found to shrink and produce extensive necrosis of human breast tumor xenografts in nu/nu mice. We examined the ability of 90Yttrium-labeled and native MAG-1 to affect the growth in nu/nu mice of cancer xenografts that were estrogen-responsive (from MCF-7 cells) and triple-negative (from MDA-MB231 cells). The growth rates of treated cells were compared to those receiving saline vehicle and those receiving 90Yttriumlabeled and native forms of the ubiquitous antibody, MOPC21. Short-term treatments (4 doses over 6 days) not only with 90Yttrium-MAG-1 but also native MAG-1 produced large reductions in size of rapidly growing tumors of both types, while both 90Yttrium- MOPC21 and native MOPC21 had no effect. Native and 90Yttrium-MAG-1 effects were similar, and arrested tumors recommenced growing soon after treatments stopped. Increasing native MAG-1 treatment to single dosing for 16 consecutive days shrank tumors of both types with no regrowth apparent over a 20-day post-treatment period of observation. Pathological examination of such tumors revealed they had undergone very extensive ([66%) necrosis
Breast Cancer Res Treat (2011) 127:631–637 Received: 17 September 2009 / Accepted: 22 June 2010 / Published online: 13 July 2010 Springer Science+Business Media, LLC. 2010
