RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Haiming Sun Jing Bai Feng Chen Yan Jin Yang Yu Lianhong Jin Songbin Fu
- چاپ و سال / کشور: 2010
Description
Several studies have investigated the associations between RAD51 G135C polymorphism and the susceptibility to breast cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 17 case control studies, including 12,153 cases and 10,245 controls, were selected. Overall, significant decreased risk was found for the additive model (OR = 0.995, 95% CI = 0.991–0.998) and dominant model (OR = 0.994, 95% CI = 0.991–0.998). In the subgroup analysis by ethnicity, statistically significantly decreased risk was found in Asians (additive model: OR = 0.977, 95% CI = 0.954–1.000 and dominant model: OR = 0.981, 95% CI = 0.963–1.000). In conclusion, this meta-analysis suggests that the RAD51 G135C polymorphism is a low-penetrant risk factor for developing breast cancer.
Breast Cancer Res Treat (2011) 125:157–161 DOI 10.1007/s10549-010-0922-z Received: 14 April 2010 / Accepted: 16 April 2010 / Published online: 8 May 2010 Springer Science+Business Media, LLC. 2010
